The first-principles approach for the analysis of pseudocontact shifts (PCSs) is questioned by comparing the experimental g values of copper(II) proteins with those derived from the anisotropy tensor obtained from the PCSs. read more

Many properties of intrinsically disordered proteins (IDPs) or protein regions (IDRs) are expected to be modulated by the nature of amino acid side chains as well as by local solvent exposure. read more

Structure‐based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. read more

Dynamic nuclear polarization (DNP) in liquid solutions can enhance 13C NMR signals at magnetic fields of 3 T and room temperature up to three orders of magnitude read more

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