The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. On activation, STIM1 C terminus changes from an inactive, tight to an active, extended conformation read more

Many properties of intrinsically disordered proteins (IDPs) or protein regions (IDRs) are expected to be modulated by the nature of amino acid side chains as well as by local solvent exposure. read more

Fluorinated amino acids can be easily incorporated in proteins expressed in human cells, allowing 19F in-cell NMR studies of proteins that would otherwise be invisible by 1H-detected in-cell NMR. read more

Metalloproteins constitute a significant fraction of the proteome of all organisms and their characterization is critical for both basic sciences and biomedical applications. read more