Vito Calderone obtained his master degree in Biological Sciences at the University of Turin in 1992 and the PhD in Protein Chemistry at the University of Turin in 1997. He has spent a part of his PhD in the Department of Biology and Biochemistry at the University of Bath. Afterwards he has been postdoc at IGBMC in Strasburg from 1997 to 1999. Then postdoc at the University of Padua from 1999 to 2002, at the University of Siena from 2002 to 2006 and at CERM (University of Florence) from 2006 to 2012. He is assistant professor at the University of Florence since 2012.
The research domain in which Vito Calderone has been involved since his degree is structural biology; in particular, his main expertise is the structural determination of proteins of biological interest through X-ray crystallography. His main research topics include structural determination of mitochondrial proteins and metalloproteins (mainly involved in electron transfer processes and in metal trafficking in the cell), application of X-ray crystallography in structure-based drug design and structural studies of metal-mediated protein–protein complexes.
He is co-author of about 70 papers published in international peer reviewed journals (H-index = 27) and has solved over 120 X-ray structures of proteins.
Protein crystallography, integrated structural biology, systems biology, bio-inorganic chemistry
1) Gourdoupis S, Nasta V, Ciofi-Baffoni S, Banci L, Calderone V (2019). In-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity. ACTA CRYST. SECTION D, STRUCTURAL BIOLOGY, vol. 75, p. 317-324, ISSN: 2059-7983, doi: 10.1107/S2059798319000214
2) Calderone V, Fragai M, Luchinat C (2018). When molecular replacement has no trivial solution: The importance of model editing in human S100Z X-ray structure solution. INORG CHIM ACTA, vol. 470, p. 402-406, ISSN: 0020-1693, doi: 10.1016/j.ica.2017.06.055
3) Calderone V, Fragai M, Gallo G, Luchinat C (2017). Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds. J BIOL INORG CHEM, p. 1-8, ISSN: 0949-8257, doi: 10.1007/s00775-017-1437-4
4) Banci L, Bertini I, Blaževitš O, Calderone V, Cantini F, Mao J, Trapananti A, Vieru M, Amori I, Cozzolino M, Carrì MT (2012).
Interaction of Cisplatin with Human Superoxide Dismutase. J AM CHEM SOC, vol. 134, p. 7009-7014, ISSN: 0002-7863, doi: 10.1021/ja211591n
5) Banci L, Bertini I, Calderone V, Cefaro C, Ciofi-Baffoni S, Gallo A, Kallergi E, Lionaki E, Pozidis C, Tokatlidis K (2011). Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. PROC NATL ACAD SCI USA, vol. 108 (6), p. 4811-4816, ISSN: 0027-8424, doi: 10.1073/pnas.1014542108
6) Calderone V, Fragai M, Luchinat C, Nativi C, Richichi B, Roelens S (2006). A high-affinity carbohydrate-containing inhibitor of matrix metalloproteinases.
CHEM MED CHEM, vol. 1, p. 598-601, ISSN: 1860-7179, doi: 10.1002/cmdc.200600020
7) Calderone, V, Forleo C, Benvenuti M, Thaller MC, Rossolini GM, Mangani S (2006). A Structure-based Proposal for the Catalytic Mechanism of the Bacterial Acid Phosphatase AphA belonging to the DDDD Superfamily of Phosphohydrolases. J MOL BIOL, vol. 355, p. 708-721, ISSN: 0022-2836, doi: 10.1016/j.jmb.2005.10.068
8) Calderone V, Casini A, Mangani S, Messori L, Orioli P (2006). Structural Investigation of Cisplatin-Protein Interactions: Selective Platination of His 19 in Cuprozinc Superoxide Dismutase. ANGEW CHEM INT ED, vol. 45, p. 1267-1269, ISSN: 1433-7851, doi: 10.1002/anie.200502599
9) Calderone V, Del Bianco C, Dolderer B, Echner H, Hartmann Hj, Luchinat C, Mangani S, Weser U (2005). The crystal structure of yeast copper thionein: The solution of a long-lasting enigma. PROC NATL ACAD SCI USA, vol. 102, p. 51-56, ISSN: 0027-8424, doi: 10.1073/pnas.0408254101
10) Calderone V (2004). Practical aspects of the integration of different software in protein structure solution. ACTA CRYST SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, vol. 60, p. 2150-2155, ISSN: 0907-4449, doi: 10.1107/S0907444904019055