Lucia Banci is Professor of Chemistry at the University of Florence. She has an extensive expertise and has provided original contributions and breakthroughs in Structural Biology and in biological NMR. She has addressed and unraveled many aspects of the biology of metal ions in biological systems.
The innovative in cell NMR approach developed by Lucia Banci and her group allows for the detection of human individual proteins in living human cells with atomic level resolution. She also exploited the extensive knowledge of structural biology approaches through NMR expertise to develop an absolutely innovative approach to vaccine design, based on the knowledge of the structure of the pathogen antigens and of the interaction pattern with antibodies, to design structure-based vaccines.
Lucia Banci is one of the founders and present Director of the Center of Magnetic Resonance (CERM) of the University of Florence. She is the Head of the Italian Core Center of the ESFRI Research Infrastructure Instruct-ERIC, and a member of the Instruct-ERIC Executive Committee and of the Council.
In-cell NMR, Structural Biology, Structural Vaccinology, Metals in biology, Iron-sulfur protein biogenesis
Camponeschi, F., Ciofi-Baffoni, S., and Banci, L., Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction, J.Am.Chem Soc., 139, 9479-9482, 2017.
Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Camponeschi F, Ciofi-Baffoni S, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Stessman HAF, Marchetto MCN, Denman L, Harshman L, Baker C, Raja A, Penewit K, Tang WJ, Ventura M, Antonacci F, Akey JM, Amemiya CT, Banci L, Gage FH, Reymond A and Eichler EE. Emergence of a Homo sapiens-specific gene family and the evolution of autism risk at chromosome 16p11.2. Nature 536: 205-209, 2016.
Barbieri L, Luchinat E and Banci L. Characterization of proteins by in cell NMR spectroscopy in cultures mammalians cells in their physiological environment. Nature Protocols 11: 1101-1111, 2016.
Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R and Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nat Chem Biol 11: 772-778, 2015.
Banci L, Camponeschi F, Ciofi-Baffoni S and Muzzioli R. Elucidating the molecular function of human BOLA2 in GRX3-Dependent anamorsin maturation pathway. J Am Chem Soc 137: 16133-16134, 2015.
Banci L, Brancaccio D, Ciofi-Baffoni S, Del Conte R, Gadepalli R, Mikolajczyk M, Neri S, Piccioli M and Winkelmann J. [2Fe-2S] cluster transfer in iron-sulfur protein biogenesis, Proc.Natl.Acad.Sci.U.S.A, 111, 6203-6208, 2014.
Luchinat E, Barbieri L, Rubino J.T, Kozyreva T, Cantini F & Banci L. In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants. Nature Commun. 5, 5502, 2014.
Banci L, Barbieri L, Bertini I, Luchinat E, Secci E, Zhao Y & Aricescu A.R. Atomic-resolution monitoring of protein maturation in live human cells by NMR. Nature Chem. Biol. 9, 297-299, 2013.
Scarselli M, Aricò B*, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley M.J, Malito E, Lo Surdo P, Comanducci M, Giuliani M.M, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M. & Rappuoli R. Rational design of a meningococcal antigen inducing broad protective immunity. Science Transl Med. 3, 91ra62, 2011.
Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K & Palumaa P. Affinity gradients drive copper to cellular destinations. Nature 465, 645-648, 2010.
Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato A and Voulgaris P. The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol 2: 367-368, 2006.
Andreini C, Banci L, Bertini I and Rosato A. Zinc through the three domains of life. J Proteome Res 5: 3173-3178, 2006.