Research outputs of the cycles already completed
| XXXI Cycle | XXX Cycle | XXIX Cycle | XXVIII Cycle | XXVII Cycle | XXVI Cycle |
Publications
Polykretis P., Luchinat E., Boscaro F. and BanciL., Methylglyoxal interaction with superoxide dismutase 1. Redox biology, 2020, 30, 101421.
Dourou, A.-M.; Brizzolara, S.; Meoni, G.; Tenori, L.; Famiani, F.; Luchinat, C.; Tonutti, P. The Inner Temperature of the Olives (Cv. Leccino) before Processing Affects the Volatile Profile and the Composition of the Oil. Food Research International 2020, 129.
Citterio F, Romano F, Meoni G, Iaderosa G, Grossi S, Sobrero A, Dego F, Corana M, Berta GN, Tenori L, Aimetti M, Changes in the Salivary Metabolic Profile of Generalized Periodontitis Patients after Non-surgical Periodontal Therapy: A Metabolomic Analysis Using Nuclear Magnetic Resonance Spectroscopy doi: 10.3390/jcm9123977, J Clin Med2020, 9, 3977
Meoni G., Tenori L., LuchinatC. Nuclear Magnetic Resonance-Based Metabolomic Comparison of Breast Milk and Organic and Traditional Formula Milk Brands for Infants and ToddlersOMICS A Journal of Integrative Biology, 2020, 24(7), pp. 424–436
Nannini G, Meoni G, Amedei A, Tenori L.Metabolomics profile in gastrointestinal cancers: Update and future perspectives. 10.3748/wjg.v26.i20.2514 World J Gastroenterol2020; 26(20): 2514-2532
Bruno F, Francischello R, Bellomo G, Gigli L, Flori A, Menichetti L, Tenori L, Luchinat C, Ravera E. Multivariate Curve Resolution for 2D Solid-State NMR spectra Anal Chem. 2020 Mar 17;92(6):4451-4458.
Bellomo G, Bologna S, Cerofolini L, Paciotti S, Gatticchi L, Ravera E, Parnetti L, Fragai M, Luchinat C., Dissecting the Interactions between Human Serum Albumin and α-Synuclein: New Insights on the Factors Influencing α-Synuclein Aggregation in Biological Fluids. J Phys Chem B. 2019, 123, 4380-4386. (IF 2.923)
Vignoli A, Ghini V, Meoni G, Licari C, Takis PG, Tenori L, Turano P, Luchinat C., High-Throughput Metabolomics by 1D NMR. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):968-994. doi: 10.1002/anie.201804736. (IF 12.257).
Meoni G, Lorini S, Monti M, Madia F, Corti G, Luchinat C, Zignego AL, Tenori L, Gragnani L., The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy. Scientific reports. 2019, 4128. doi: 10.1038/s41598-019-40028-4. (IF 4.525)
Romano F, Meoni G, Manavella V, Baima G, Mariani GM, Cacciatore S, Tenori L, Aimetti M. Effect of non-surgical periodontal therapy on salivary metabolic fingerprint of generalized chronic periodontitis using nuclear magnetic resonance spectroscopy. Arch Oral Biol. 2019 Jan;97:208-214. (IF 1.663)
Polykretis P, Cencetti F, Donati C, Luchinat E, Banci L. Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR. Redox Biol. 2019; 21:101102. (IF 7.126)
Polykretis, P., Luchinat, E., Bonucci, A., Giachetti, A., Graewert, M. A., Svergun, D. I., & Banci, L. (2019). Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach. IUCrJ, 6(5). (2019) doi:10.1107/S205225251901073X
Gourdoupis S., Nasta V., Ciofi-Baffoni S., Banci L., Calderone V. In-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity doi: 10.1107/S2059798319000214. Acta Crystallogr D Struct Biol. 2019;75(Pt 3):317-324 (IF 3.227)
Bellomo G, Bologna S, Gonnelli L, Ravera E, Fragai M, Lelli M, Luchinat C. Aggregation kinetics of the Aβ1-40 peptide monitored by NMR. Chem Commun (Camb). (2018) 7601-7604. doi: 10.1039/c8cc01710g. (IF 6.290)
S. Paciotti, G. Bellomo, L. Gatticchi and L. Parnetti, Front. Neurol., Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools, Front. Neurol., (2018) DOI:10.3389/fneur.2018.00415
Tenori, L., Santucci, C., Meoni, G., Morrocchi, V., Matteucci, G., Luchinat, C. NMR metabolomic fingerprinting distinguishes milk from different farms, Food Research Int., 113, (2018), 131-139. (IF 3.520)
Romano F., Meoni G., Manavella V. , Baima G., Tenori L., Cacciatore S. , Aimetti M., Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis, through nuclear magnetic resonance-based metabolomics. J Periodontology (2018) doi: 10.1002/JPER.18-0097 (IF 3.392)
Romano F., Meoni G., Manavella V. , Baima G., Tenori L., Cacciatore S. , Aimetti M., Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis, through nuclear magnetic resonance-based metabolomics. J Periodontology (2018) doi: 10.1002/JPER.18-0097 (IF 3.392)
Basoglu A, Sen,I., Meoni,G., Tenori,L.,Naseri A., NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis, Mediators of Inflammation, doi. 10.1155/(2018)/8016510, (2018) (IF 3.232)
Gourdoupis S, Nasta V, Calderone V, Ciofi-Baffoni S, Banci L. IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex. J Am Chem Soc. (2018);140, 14401-14412 (IF 14.357)
López-Sagaseta J, Beernink PT, Bianchi F, Santini L, Frigimelica E, Lucas AH, Pizza M, Bottomley MJ. Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. Nat Communication . 2018 Feb 6;9(1):528. doi: 10.1038/s41467-018-02827-7. (Impact Factor : 12.124)
Hou, MM., Polykretis, P., Luchinat, E., Wang, X., Chen, SN, Zuo, HH, Yang, Y., Chen, JL, Ye, Y, Li, C., Banci, L., and Su, X. C., Structural insights into the first BIR domain of XIAP in solution and interaction with copper in vitro and in living cells, Scientific Reports 7, 16630, 2017, doi:10.1038/s 41598-017-16723-5, (IF 4.259)
Polykretis P, Delfino G, Petrocelli I, Cervo R, Tanteri G, Montori G, Perito B, Branca J, Morucci G and Gulisano M. Evidence of immunocompetence reduction induced by cadmium exposure in honey bees (Apis mellifera), Environmental Pollution, 218: 826-834, 2016 (IF 4.839)
Communications at Conferences
Giovanni Bellomo:
- Challenges for magnetic resonance in life sciences, 27/05/2018 - 01/06/2018, Grosseto (Italy), poster title: Aggregation kinetics of Aβ1-40 peptide monitored by NMR.
- CMRBS 2018, 19/08/2018 - 24/08/2018, University College, (Dublin, Ireland) poster title: Human serum albumin and α-synuclein partnership: dissecting the interaction modes by NMR.
- Update sulla determinazione dell’α-sinucleina nei fluidi biologici: focus su α-syn RT-QuIC/PMCA, 06/09/2018, Azienda Ospedaliera di Perugia (Perugia, Italy), Oral presentation: RT-QuIC e PMCA, un approccio biofisico alla diagnosi.
Federica Bianchi:
- R&D days, GSK Vaccine Siena Italy 12-13 july 2016. Presenting of a poster: Screening and characterization of cross-reactive anti-factor H binding protein (fHbp) recombinant human monoclonal antibodies produced by memory B cells from Bexsero vaccinated individuals
- Phd workshop GSK Vaccine Siena Italy presenting poster:Screening and characterization of cross-reactive anti-factor H binding protein (fHbp) recombinant human monoclonal antibodies produced by memory B cells from Bexsero vaccinated individuals
- 14 Th EIMID, DeVere hotel Sandford –on-thames Oxford, UK 27-29 september 2017 presenting a poster: Characterization of the human immune response after vaccination with Bexsero through structural and functional studies of human Fabs from a longitudinal memory B-cell repertoire.
- Phd workshop GSK Vaccine Siena italy 9 november 2017 oral presentation: Characterization of the human immune response after vaccination with Bexsero through structural and functional studies of human Fabs from a longitudinal memory B-cell repertoire.
Spyridon Gourdoupis:
- 3rd MEETING OF THE COST ACTION CA15133; The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet); Zagreb, Croatia, 12-13 June 2018 (poster presentation)
Gaia Meoni:
Oral Communications
- Pre-Meetng “Liver Gymnasium 3” held in Padova on 22 September 2016 “A serum metabolomic analysis of HCV-infected patients successfully treated with IFN-free DAA regimens”.
- Focus on Breast Cancer 2017, organized jointly by the Istituto Toscano Tumori and Prato Hospital (Oncology Department), on 6-7 July 2017, Prato, Italy: “Metabolomic analysis by nuclear magnetic resonance spectroscopy discriminates hormone receptor positive/HER2 negative breast cancer cell lines resistant to palbociclib”.
- MOVISS workshop Vorau (Austria) 20-23 September 2017 “A serum metabolomic analysis of HCV-infected patients successfully treated with IFN-free DAA regimens”.
- Festival della Scienza Genova (Italy) 4 November 2017 “Nuclear Magnetic Resonance: food studies”
- 8th International Symposium on Recent Advances in Food Analysis RAFA 2017 organized jointly by the University of Chemistry and technology, Prague (UCT), Czech Republic and RIKILT, Wageningen University & Research, the Netherlands, on 7-10 November 2017 in Prague, Czech Republic: “NMR-based metabolomics to understand the abscission phenomenon of olives and for the characterization of wines”.
- Falling walls Lab 27 September 2018, aula magna del Rettorato dell’Università di Firenze (Italy), “Breaking the wall of special coffees”
Posters
- XLV National Congress of Magnetic Resonance GIDRM held in Modena (Italy) from 5 to 7 September 2016: “A serum metabolomic analysis of HCV-infected patients successfully treated with IFN-free DAA regimens”.
- Pre-Meetng “Liver Gymnasium 3” held in Padova on 22 September 2016 “A serum metabolomic analysis of HCV-infected patients successfully treated with IFN-free DAA regimens”.
- PhD Day 8 University of Florence Sesto Fiorentino 24 May 2016 “A serum metabolomic analysis of HCV-infected patients successfully treated with IFN-free DAA regimens”
- 8th International Symposium on Recent Advances in Food Analysis RAFA 2017 on 7-10 November 2017 in Prague, Czech Republic: “NMR-based metabolomics to improve olive tree productivity unravelling metabolic behavior of fruitlet drop”.
- XLVI National Congress of Magnetic Resonance GIDRM held in Salerno (Italy) from 27 to 29 September 2017: “NMR-based metabolomics to understand the abscission phenomenon of olives and for the characterization of wines”.
- 8th International Symposium on Recent Advances in Food Analysis RAFA 2017 on 7-10 November 2017 in Prague, Czech Republic: “NMR-based metabolomics to improve olive tree productivity unravelling metabolic behavior of fruitlet drop”.
Eriberto Natali
- 9th annual PhD workshop in GSK Siena (november 2016), PhD project was presented with a poster.
- 10th annual PhD workshop in GSK Siena (november 2017), PhD project was presented orally.
- A PhD project poster was presented during the R&D days in GSK Siena in july 2017 and july 2018.
Panagis Polykretis
- Polykretis, P., Luchinat, E., Su, X. C. & Banci, L. Characterization of XIAP-BIR1 in mammalian cells by NMR [poster]. 14th Chianti Workshop, Magnetic Resonance for Cellular Structural Biology, 5 - 10 June 2016, Grosseto, Italy.
- Hou, M. M., Polykretis, P., Luchinat, E., Wang, X., Chen, S. N., Zuo, H. H., ... & Banci, L. Structural investigation of XIAP-BIR1 in solution and in living cells [poster]. Instruct Biennial Structural Biology Meeting, 24 - 26 May 2017, Brno, Czech Republic.
- Polykretis, P., Luchinat, E., Graewert, M. A., Bonucci, A., Giachetti, A., Svergun, D. I., & Banci, L. Structural characterization of full length XIAP by integrating NMR, SAXS and EPR data [poster]. EMBO Workshop, Challenges for Magnetic Resonance in life sciences, 27 - 31 May 2018, Grosseto, Italy.
Publications
Vignoli, A.; Muraro, E.; Miolo, G.; Tenori, L.; Turano, P.; Di Gregorio, E.; Steffan, A.; Luchinat, C.; Corona, G. Effect of Estrogen Receptor Status on Circulatory Immune and Metabolomics Profiles of Her2-Positive Breast Cancer Patients Enrolled for Neoadjuvant Targeted Chemotherapy. Cancers 2020, 12 (2).
Rocca M. S.; Vignoli A.; Tenori L.; Ghezzi M.; De Rocco Ponce M.; VatsellasG.;Thanos D.; Padrini R.; Foresta C.; De ToniL. Evaluation of Serum/Urine Genomic and Metabolomic Profiles to Improve the Adherence to Sildenafil Therapy in Patients with Erectile Dysfunction. doi.org/10.3389/fphar.2020.602369Front. Pharmacol. 2020, 11.
Vignoli, A., Tenori, L., Luchinat, C., Saccenti, E. Differential Network Analysis Reveals Molecular Determinants Associated with Blood Pressure and Heart Rate in Healthy Subjects DOI: 10.1021/acs.jproteome.0c00882 (2020) J.Proteom Res
Vignoli A, Santini G, Tenori L, Macis G, Mores, Macagno N, Pagano F, Higenbottam T Luchinat C, Montuschi P, NMR-Based Metabolomics for the Assessment of Inhaled Pharmacotherapy in Chronic Obstructive Pulmonary Disease Patients, J.Proteom Res.2020, 19, 64-74
Vignoli, A.; Tenori, L.; Giusti, B.; Valente, S.; Carrabba, N.; Balzi, D.; Barchielli, A.; Marchionni, N.; Gensini, G. F.; Marcucci, R.; Gori, A. M.; Luchinat, C.; Saccenti, E. Differential Network Analysis Reveals Metabolic Determinants Associated with Mortality in Acute Myocardial Infarction Patients and Suggests Potential Mechanisms Underlying Different Clinical Scores Used to Predict Death. J.Proteom Res.2020, 19 (2), 949–961.
Vignoli A, Paciotti S, Tenori L, Eusebi P, Biscetti L, Chiasserini D, Scheltens P, Turano P, Teunissen C, Luchinat C, Parnetti L., Fingerprinting Alzheimer's Disease by 1H Nuclear Magnetic Resonance Spectroscopy of Cerebrospinal Fluid., J Proteome Res.2020, 19, 1696-1705.
Basoglu, A., Baspinar, N., Tenori, L., Vignoli, A., and Gulersoy, E., Effects of boron supplementation on peripartum dairy cow's health, Biol.Trace Elem.Res., Doi:10.1007/s12011-017-0971-9, 1-8, 2017 (IF 2.399)
McCartney, A., Vignoli, A., Hart, C, Tenori, L., Luchinat, C., Biganzoli, L., and Di Leo, A., De-escalating and escalating treatment beyond endocrine therapy in patients with luminal breast cancer, Breast, doi: 10.1016/j.breast.2017.06.021, 2017 (IF 2.801)
Hart, C.D., Vignoli, A., Tenori, L., Uy, G, Ta Van, T., Adebamowo, C., Hossain, S.M., Biganzoli, L., Risi, E., Love, R., Luchinat, C., and Di Leo,A., Serum metabolomic profiles identify ER-positive early breast cancer patients at increased risk of disease recurrence in a multicentre population, Clin. Cancer. Res. DOI:10.1158/1078-0432.CCR-16-1153, 2016 (IF 8.738)
Mercatelli, E., Barbieri, L., Luchinat, E., and Banci, L., Direct Structural Evidence of Protein Redox Regulation Obtained by in-cell NMR, BBA - Molecular Cell Research, 1863: 198-204, 2016 (IF 5.019)
Basoglu, A., Tenori, L., Vignoli, A., Yildiz, R. and Baspinar, N., NMR based metabolomics evaluation in calves with acute bronchopneumonia: A new approach for biomarker/s, Metabolomics, 12: 1-10, 2016 (IF 3.661)
Vignoli, A., Rodio, D. M., Bellizzi, A., Sobolev, A., Anzivino, E., Mischitelli, M., Tenori, L., Marini, F., Scrivo, R., Valensini, G., Francia, A., Morreale, M., Ciardi, MR, Iannetta, M., Capanella, C., Capitani, D., Mannina, L., Luchinat, C., and Pietropaolo, V. Nuclear magnetic resonance based metabolomic approach to study urines of chronic inflammatory rheumatic diseases, Anal. Bioanal. Chem. 409, 1405-1413, 2017 (IF 3.431)
Communications at Conferences
Alessia Vignoli:
- Oral communication: XLV National Congress of Magnetic Resonance GIDRM Modena 5-7 September 2016
Publications
Perrin E, Ghini V, Giovannini M, Di Patti F, Cardazzo B, Carraro L, Fagorzi C, Turano P, Fani R, Fondi M. Diauxie and co-utilization of carbon sources can coexist during bacterial growth in nutritionally complex environments. Nat Commun.2020 Jun 19;11(1):3135.
Ruocco C., Ragni M., Rossi F., Carullo P., Ghini V., Piscitelli F., Cutignano A. Manipulation of dietary amino acids prevents and reverses obesity in mice through multiple mechanisms that modulate energy homeostasis, Diabetes69 (11), 2324-2339, 2020
Ghini V, Laera L, Fantechi B, Monte F, Benelli M, McCartney A, Tenori L Metabolomics to Assess Response to Immune Checkpoint Inhibitors in Patients with Non-Small-Cell Lung Cancer. Cancers202012 (12), 3574
Ghini V.; Tenori L.; Capozzi F.; Luchinat C.; Bub A.; Malpuech-Brugere C.; Orfila C.; Ricciardiello L.; BordoniA. DHA-Induced Perturbation of Human Serum Metabolome. Role of the Food Matrix and Co-Administration of Oat β-Glucan and Anthocyanins. Nutrients2020, 12
Ghini V, L Tenori, M Pane, A Amoruso, G Marroncini, DF Squarzanti Effects of Probiotics Administration on Human Metabolic Phenotype Metabolites10 (10), 396
Antonaros F, Ghini V, Pulina F, Ramacieri G, Cicchini E, Mannini E, Martelli A, Feliciello A, Lanfranchi S, Onnivello S, Vianello R, Locatelli C, Cocchi G, Pelleri MC, Vitale L, Strippoli P, Luchinat C, Turano P, Piovesan A, Caracausi M. Plasma metabolome and cognitive skills in Down syndrome Sci Rep.2020 26;10, 10491
Ciambellotti S, Pozzi C, Mangani S, Turano P. Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin. Chem. Eur. J.2020 May 7;26(26):5770-5773
Schirò A, A. Carlon, G. Parigi, G. Murshudov, V. Calderone, E. Ravera, C. Luchinat, On the complementarity of X-ray and NMR data, J. Struct. Biol.X (2020) 4, 100019
Andralojc, W., Hiruma, Y., Liu, W.-M., Ravera, E., Nojiri, M., Parigi, G., Luchinat, C., and Ubbink, M., Identification of productive and futile encounters in an electron transfer protein complex, Proc.Natl.Acad.Sci.USA, 114, E1840-E1847, 2017 (IF 9.423).
Pozzi, C., Ciambellotti, S., Bernacchioni, C., Di Pisa, F., Mangani, S., and Turano, P., Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (µ3-oxo)tris [(µ2-peroxo)] triiron(III) cluster, Proc.Natl.Acad.Sci.USA, 114, 2580-2585, 2017 (IF 9.423).
Zanzoni, S., Pagano, K, D'Onofrio, M., Assfalg, M., Ciambellotti, S., Bernacchioni, C., Turano, P., Aime, S., Ragona, L., and Molinari, H., Unsatured long chain fatty acids are preferred ferritin ligands enhancing iron biomineralization, Chemistry, 23, 9879-9887, 2017 (IF 5.317).
Sala, D., Ciambellotti, S., Giachetti, A., Turano, P., and Rosato, A., Investigation of the Iron(II) Release Mechanism of Human H-Ferritin as a Function of pH, J.Chem Inf.Model., 57, 2112-2118, 2017 (IF 3.760).
Bernacchioni, C., Ghini, V., Cencetti, F., Japtok, L., Donati, C., Bruni, P., and Turano, P., NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells, Mol.Oncol., 11, 517-533, 2017 (IF 5.314).
Ghini, V., Di Nunzio, M., Tenori, L., Valli, V., Danesi, F, Capozzi, F., Luchinat, C., and Bordoni, A., Evidence of a DHA signature in the lipidome and metabolome of human hepatocytes, Int.J.Mol.Sci., 18, E359-, 2017 (IF 3.257).
Cerofolini, L., Giuntini, S., Louka, A., Ravera, E., Fragai, M., and Luchinat, C., High-resolution solid state NMR characterization of ligand binding to a protein immobilized in a silica matrix, J.Phys.Chem B, 121, 8094-8101, 2017 (IF 3.302).
Carlon, A., Ravera, E., Hennig, J., Parigi, G., Sattler, M., and Luchinat, C., Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure, J.Am.Chem.Soc., 138: 1601-1610, 2016 (IF 13.038).
Ravera, E., Ciambellotti, S., Cerofolini, L., Martelli, T., Kozyreva, T., Bernacchioni, C., Giuntini, S., Fragai, M., Turano, P., and Luchinat, C., Solid-state NMR of PEGylated proteins, Angew.Chem.Int.Ed, 55: 1-5, 2016 (IF 11.336).
Uzarska, M. A., Nasta, V., Weiler, B. D., Spantgar, F., Ciofi-Baffoni, S., Saviello, M., Gonnelli, L., Muhlenhoff, U., Banci, L. and Lill, R., Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins, Elife 5: e16673, 2016 (IF 8.519).
Carlon, A., Ravera, E., Andralojc, W., Parigi, G., Murshudov, G. N., and Luchinat, C., How to Tackle Protein Structural Data from Solution and Solid State: An integrated Approach, Progress in NMR Spectroscopy, 92-93: 54-70, 2016 (IF 7.237).
Martelli, T., Ravera, E., Louka, A., Cerofolini, L., Hafner, M., Fragai, M., Becker, C. F. W., and Luchinat, C., Atomic-Level Quality Assessment of Enzymes Encapsulated in Bioinspired Silica, Chem. Eur. J., 22: 425-432, 2016 (IF 5.771).
Richichi, B., Baldoneschi, V., Burgalassi, S., Fragai, M., Vullo, A., Akdemir, A., Dragoni, E., Louka, A., Mamusa, M., Monti, D., Berti, D., Novellino, E., Rosa, G. and Supuran, CT., A divalent PAMAM-based matrix metalloproteinase/carbonic anhydrase inhibitor for the treatment of dry eye syndrome, Chem. Eur. J., 5: 1714-1721, 2016 (IF 5.771).
Ravera, E., Cerofolini, L., Martelli, T., Louka, A., Fragai, M. and Luchinat, C., 1H detected solid state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials, Scientific Reports, 6: 27851-doi: 10.1038/srep27851, 2016 (IF 5.578).
Saccenti, E., Menichetti, G., Ghini, V., Remondini, D., Tenori, L. and Luchinat, C., Entropy-Based Network Representation of the Individual Metabolic Phenotype. J. Proteome Res., 15: 3298-3307, 2016 (IF 5.001).
Andralojc, W., Ravera, E., Salmon, L., Parigi, G., Al-Hashimi, HM. and Luchinat, C., Inter-helical conformational preferences of HIV-1 TAR-RNA from Maximum Occurrence analysis of NMR data and Molecular Dynamics simulations. Phys. Chem. Chem. Phys., 18: 5743-5752, 2016 (IF 4.493).
Bernacchioni, C., Ghini, V., Theil, EC. and Turano, P., Modulating in permeability of the ferritin channels, RSC Advances, 6: 21219-21227, 2016 (IF 3.84).
Ghini V, Saccenti E, Tenori L, Assfalg M and Luchinat C. Allostasis and resilience of the human individual metabolic phenotype. J Proteome Res 14: 2951-2962, 2015.(IF 4.245)
Ghini V, Unger F, Tenori L, Turano P, Juhl H and David KA. Metabolomics profiling of pre and post anesthesia plasma samples obtained via Ficoll separation. Metabolomics 11: 1769-1778, 2015.(IF 3.965)
Andralojc W, Berlin K, Fushman D, Luchinat C, Parigi G, Ravera E and Sgheri L. Information content of long-range NMR data for the characterization of conformational heterogeneity. J Biomol NMR 62: 353-371, 2015.(IF 3.305)
Rinaldelli, M., Carlon, A., Ravera, E., Parigi, G., and Luchinat, C., FANTEN: a new web-based interface for the analysis of magnetic anisotropy-induced NMR data, J Biomol NMR, 61, 21-34, 2015 (IF 3.141).
Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P and Mangani S. Iron bindind to human heavy-chain ferritin. Acta Crystallogr D Biol Crystallogr 71: 1909-1920, 2015.(IF 2.674)
Bernacchioni, C., Ciambellotti, S., Theil, E. C., and Turano, P., Is His54 a gating residue for the ferritin ferroxidase site?, Biochim.Biophys.Acta, 9639, 47-53, 2015 (IF 2.089)
Bernacchioni, C., Ghini, V., Pozzi, C., Di Pisa, F., Theil, E. C., and Turano, P., Loop Electrostatics Modulates the Intersubunit and Intercage Interactions in Ferritin, ACS Chem Biol., 9, 2517-2525, 2014 (IF 5.356).
Andralojc, W., Luchinat, C., Parigi, G., and Ravera, E., Exploring regions of conformational space occupied by two-domain proteins, J.Phys.Chem.B, 118, 10576-10587, 2014 (IF 3.607).
Theil, E. C., Turano, P., Allegrozzi, M., Ghini, V., and Bernacchioni, C., Coordinating Subdomains of Ferritin Protein Cages with Catalysis and Biomineralization viewed from the C4 Cage Axes, J.Biol.Inorg.Chem., 19, 615-622, 2014 (IF 3.353).
Ravera, E., Carlon, A., and Parigi, G., Pairwise binding competition experiments for sorting hub-protein/effector interaction hierarchy and simultaneous equilibria., J.Biomol.NMR, 60, 29-36, 2014 (IF 3.305).
Castaldo, C., Ciambellotti, S., Pablo-Latorre, R., Lalli, D., Porcari, V., and Turano, P., Soluble variants of human recombinant glutaminyl cyclase, Plos ONE, 8, e71657-, 2013 (IF 3.730).
Communications at Conferences
Witold Andrałojć:
- 4th Annual User group Meeting of Bio-NMR, Warsaw, 5 - 9.05.2014
- Magnetic resonance for cellular structural biology, Grosseto, 1 - 6.06.2014
- New Developments in Experimental and Theoretical Techniques for the Study of Paramagnetic Inorganic Materials, Cambridge, 16 – 18.09.2014
- pNMR: from rags to riches, Challenges and potentials of NMR on paramagnetic molecules, Prague, 4 - 5.07.2015
- Magnetic resonance for cellular structural biology, Grosseto, 5 - 10.06.2016
Azzurra Carlon:
- Second BioMedBridges Annual General Meeting, Florence, Italy (10 - 11 March 2014)
- 4th Annual Bio-NMR User Meeting, Warsaw, Poland (5 - 8 May 2014). Joint refinement of biomolecular structures by paramagnetic NMR and X-ray data
- Magnetic Resonance for Cellular Structural Biology, Grosseto, Italy (1 - 6 June 2014). Conformational variability in multi-domain proteins by paramagnetic NMR
- Euromar 2014 Magnetic Resonance Conference, Zurich, Switzerland (29 June - 3 July 2014). Paramagnetic NMR tools for biomolecular structures and dynamics
- IDPbyNMR Final Meeting, Grosseto, Italy (21 - 26 September 2014). Paramagnetic NMR tools for the investigation of protein structural variability
- XLIV National Congress on Magnetic Resonance, Rome, Italy (28-30 September 2015). Simultaneous refinement of biomolecular structures by long range paramagnetic NMR data and Xray data (1st prize poster competition winner)
Silvia Ciambellotti:
- FEBS Young Scientists’ Forum 2016, Kuşadası, Turkey, 31 August-2 September 2016, selected for oral communication
- FEBS congress 2016, Ephesus/Kuşadası, Turkey, 3-8 September 2016
- GIDRM NMR Day: "Industrial applications of proteins: what role for NMR?”; Florence, Italy, 15 June 2016
- School of Nanomedicine 2015, Bari, Italy, 2-4 December 2015.
- “Ferritin as a protein-based nanocarrier for drug delivery”, Bari, Italy; Nanomedicine school, 2-4 December 2015.
- Summer school in “Chemistry of metals in biological systems”, Louvain La-Neuve, Belgium, 7-14 September 2014.
- GIDRM Workshop: “In-cell NMR analysis of biomolecular structure and function”, Florence, Italy, 6th December 2013.
Veronica Ghini:
- 1st Annual meeting of the European Project “Propag-ageing”. Sesto Fiorentino, 10-11 October 2016.
- 4th International Conference of Foodomics, Cesena, 8-9 October 2015.
- XLIV GIDRM National Congress on Magnetic Resonance, Rome, 28-30 September 2015. Participation with an oral communication: “Allostasis and resilience of the human individual metabolic phenotype”. GIDRM Young Fellowship grant
- EMBO practical course on “Metabolomics Bioinformatics for Life Scientists”, Wellcome Genome Campus, Cambridge, 16-20 February 2015. EMBO Travel Fellowship grant
- ANBI Summer School in Biostatistics: “Dall’analisi univariata alle analisi multivariate negli studi cross-section e negli studi longitudinali”, Bologna, 19-20 June 2014.
- GIDRM Workshop: “In-cell NMR analysis of biomolecular structure and function”, Florence, 6 December 2013.
Alexandra Louka:
- IDPbyNMR final meeting – “ High resolution tools to understand the functional role of protein intrinsic disorder”. Riva del Sole, Castiglione della Pescaia, Grosseto, Italy, 21-26 September 2014
- Instruct Biennial Meeting 20-22 May 2015 Florence, Italy
- Chianti workshop 2016, 5-10 June 2016 Principina Terra, Grossetto, Italy.
Veronica Nasta:
- BioNMR-4th Users Meeting, Warsaw (Poland), 4-9.5.2014
- Magnetic resonance for cellular structural biology, Grosseto (Italy), 1-6.6.2014
- PhD Day5, the day dedicated to the PhD students, Firenze (Italy), 29.5.2014
- Instruct Biennial Meeting, Florence, (Italy), 20-22.5.2015
- PhD Day6, the day dedicated to the PhD students, Firenze (Italy) 27.5.2015
- IUBMB Symposium, FeS 2015 - Iron Sulfur Cluster Biogenesis and Regulation, Bergamo, (Italy) 23-26.6.2015. “Young Investigator Award”, sponsored by the International Union of Biochemistry and Molecular Biology
- FEBS-IUBMB WORKSHOP BIOINTERACTOMICS from Biomolecular Interactions to Networks, Sevilla, (Spain) 17-20.5.2016. FEBS Youth Travel Funds (YTF) Awards
- Chianti Workshop on Magnetic Resonance for Cellular Structural Biology, Principina Terra, Grosseto, (Italy), 5-10.6.2016.
Publications
Bertarello, A., Schubeis, T., Fuccio, C., Ravera, E., Fragai, M., Parigi, G., Emsley, L., Pintacuda, G., and Luchinat, C., Paramagnetic properties of a crystalline iron-sulfur protein by magic-angle spinning NMR spectroscopy, Inorg Chem, 56, 6624-6629, 2017 (IF 4.857).
Lal, P., Cerofolini, L., D'Agostino, VG, Zucal, C., Fuccio, C., Bonomo, I, Dassi, E., Giuntini, S., Di Maio, D., Vishwakarma, V., Preet, R., Williams, SN, Fairlamb, MS, Munk, R, Lehrmann, E, Abdelmohsen, K, Elezgarai, SR, Luchinat, C., Novellino, E., Quattrone, A., Biasini, E, Manzoni, L, Gorospe, M, Dixon, DA, Seneci, P, Marinelli, L., Fragai, M., and Provenzani, A., Regulation of HuR structure and function by dihydrotanshione-I, Nucleic Acids Res, Doi: 10.1093/nar/gkx623, 2017 (IF 10.162).
Hosek, T., Calcada, E. O., Nogueira, M., Salvi, M., Duarte Pagani, T., Felli, I. C and Pierattelli, R., Strucutral and dynamic characterization of the molecular hub E1A from human adenovirus, Chem. Eur. J., 22: 13010-13013, 2016 (IF 5.771).
Luchinat, E., Secci, E., Cencetti, F. and Bruni, P., Sequential protein expression and selective labeling for in-cell NMR in human cells, BBA General Subjects, 1860: 527-533, 2016 (IF 4.381).
Eftekharzadeh, B., Piai, A., Chiesa, G., Mungianu, D., Grcia, J., Pierattelli, R., Felli, I.C. and Salvatella, X., Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract, Biophys. J., 110: 2361-2366, 2016 (IF 3.874).
Cukrov, D., Zemiani, M., Brizzolara, S., Cestaro, A., Licausi, F., Luchinat, C., Santucci, C., Tenori, L., Van Veen, H., Zuccolo, A., Ruperti, B., and Tonutti, P., Extreme Hypoxic Conditions Induce Selective Molecular Responses and Metabolic Reset in Detached Apple Fruit, Front. Plant Sci., 7: 146, 2016 (IF 3.360).
Piai, A., Calcada, E. O., Tarenzi, T., del Grande, A., Varadi, M., Tompa, P., Felli, I. C., and Pierattelli, R., Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy, Biophys. J., 110: 372-381, 2016 (IF 3.874).
Fuccio, C., Luchinat, E., Barbieri, L., Neri, S. and Fragai, M., Algal autolysate medium to label proteins for NMR mammalian cells. J.Biomol.NMR, doi: 10.1007/s10858-016-0026-0: 2016 (IF 3.141).
Piai, A., Gonnelli, L., Felli, I. C., Pierattelli, R., Kazimierczuk, K., Grudziaz, K., Kozminski, W., and Zawadzka-Kazimierczuk, A., Amino acid recognition for automatic resonance assignment of intrisically disordered proteins, J.Biomol.NMR, 2016 (IF 3.141).
Secci, E., Luchinat, E., and Banci, L., The Casein Kinase 2-Dependent Phosphorylation of NS5A Domain 3 from Hepatitis C Virus Followed by Time-Resolved NMR Spectroscopy, Chem.Bio.Chem., 17: 328-333, 2016 (IF 3.088).
Saccenti, E., Suarez-Diez, M., Luchinat, C., Santucci, A., and Tenori, L., Probabilistic networks of blood metabolites in healthy subjects as indicators of latent cardiovascular risk, J.Proteome Res., 14, 1011-1111, 2015 (IF 5.001).
Santucci C, Tenori L and Luchinat C. NMR fingerprinting as a tool to evaluate post-harvest time-related changes of three agricultural products. Food res Intl 75: 106-114, 2015.(IF 3.050)
Santucci C, Brizzolara S and Tenori L. Comparison of frozen and fresh apple pulp for NMR-based metabolomic analysis. Food Analytical Methods 8: 2135-2140, 2015.(IF 1.96)
Brutscher B, Felli IC, Gil-Caballero S, Hošek T, Kümmerle R, Piai A, Pierattelli R and Sólyom Z. NMR Methods for the study of instrinsically disordered proteins structure, dynamics, and interactions: General overview and practical guidelines. Adv Exp Med Biol 870: 122, 2015.
Breydo, L., Reddya, K. D., Piai, A., Felli, I. C., Pierattelli, R., and Uversky, V. N., The crowd you're in with: Effects of different types of crowding agents on protein aggregation, Biochim.Biophys.Acta., 1844, 346-357, 2014 (IF 3.848).
Piai, A., Hošek, T., Gonnelli, L., Zawadzka-Kazimierczuk, A., Kozminski, W., Brutscher, B., Bermel, W., Pierattelli, R., and Felli, I. C., "CON-CON" assignment strategy for highly flexible intrinsically disordered proteins, J.Biomol.NMR, 60, 209-218, 2014 (IF 3.305).
Banci, L., Barbieri, L., Bertini, I., Luchinat, E., Secci, E., Zhao, Y., and Aricescu, A. R., Atomic-resolution monitoring of protein maturation in live human cells by NMR, Nat.Chem.Biol., 9, 297-299, 2013 (IF 14.690).
Banci, L., Barbieri, L., Luchinat, E., and Secci, E., Visualization of redox-controlled protein fold in living cells, Chem.Biol., 20, 747-752, 2013 (IF 5.829).
Bermel, W., Felli, I. C., Gonnelli, L., Kozminski, W., Piai, A., Pierattelli, R., and ZawadzkaKazimierczuk, A., High-dimensionality 13C direct-detected NMR experiments for the automatic assignment of intrinsically disordered proteins, J.Biomol.NMR, 57: 353-361, 2013 (IF 2.845).
Felli, I. C., Piai, A., and Pierattelli, R., Recent advances in solution NMR studies: 13C direct detection for biomolecular NMR applications, Ann.Rep.NMR Spectroscop., 359-418, 2013 (IF 1.667).
Bermel, W., Bertini, I., Gonnelli, L., Felli, I. C., Kozminski, W., Piai, A., Pierattelli, R., and Stanek, J., Speeding up sequence specific assignment of IDPs, J.Biomol.NMR, 53, 293301, 2012 (IF 3.612).
Communications at Conferences
Claudio Santucci:
- IV GIDRM Workshop on NMR applications on food science. University La Sapienza (Rome). 19th -20th June 2014
Alessandro Piai:
- 3rd Bio-NMR Annual User Meeting “NMR and protein dynamics in structural biology” (10-13 June 2013, Budapest, Hungary)
- EMBO workshop “Magnetic resonance for cellular structural biology” (1-6 June 2014, Principina Terra, Italy)
- EUROMAR 2014 conference (29 June - 3 July 2014, Zurich, Switzerland)
- IDPbyNMR meeting “High resolution tools to understand the functional role of protein intrinsic disorder” (21-26 September 2014, Riva del Sole, Italy)
- 4th international workshop of expression, structure and function of membrane proteins (28 June – 2 July 2015, Firenze, Italy)
- teacher at the PhD course “Biomolecular NMR” (13-17 October 2014, Gothenburg, Sweden).
Publications
Hosek, T., Calcada, E. O., Nogueira, M., Salvi, M., Duarte Pagani, T., Felli, I. C and Pierattelli, R., Strucutral and dynamic characterization of the molecular hub E1A from human adenovirus, Chem. Eur. J., 22: 13010-13013, 2016 (IF 5.771).
Valasatava, Y., Rosato, A., Banci, L. and Andreini, C., Metalpredator: a web server to predict iron-sulfur cluster binding proteomes, Bioinformatics, 32: 2850-2852, 2016 (IF 4.981).
Rosato, A., Valasatava, Y. and Andreini, C., Minimal functional sites in metalloproteins and their usage in strucutral bioinformatics. Int.J.Mol.Sci., 17: 671-DOI: 10.3390/ijms17050671, 2016 (IF 3.257).
Valasatava Y, Andreini C and Rosato A. Hidden relationship between metalloproteins unveiled by structural comparison of their metal sites. Scientific Reports 5: 9486, 2015.(IF 5.578)
Hosek, T., Gil-Caballero, S., Pierattelli, R., Brutscher, B., and Felli, I. C., Longitudinal relaxation properties of 1Hn and 1Há determined by direct-detected 13C NMR experiments to study intrinsically disordered, J.Magn.Reson., 254, 19-26, 2015 (IF 2.315).
Valasatava, Y., Rosato, A., Cavallaro, G., and Andreini, C., MetalS3, a database-mining tool for the identification of structurally similar metal sites, J.Biol.Inorg.Chem., 19, 937-945, 2014 (IF 3.353).
Gil, S., Hosek, T., Solyom, Z., Kümmerle, R., Brutscher, B., Pierattelli, R., and Felli, I. C., NMR studies of intrinsically disordered proteins near physiological conditions, Angew.Chem.Int.Ed., 52, 11808-11812, 2013 (IF 13.734).
Andreini, C., Cavallaro, G., Rosato, A., and Valasatava, Y., MetalS2: a tool for the structural alignment of minimal functional sites in metal-binding proteins and nucleic acids, J.Chem.Inf.Model., 53, 3064-3075, 2013 (IF 4.304).
Calcada, E. O., Felli, I. C., Hosek, T., and Pierattelli, R., The heterogeneous structural behaviour of E7 from HPV16 revealed by NMR spectroscopy, ChemBioChem, 14, 18761882, 2013 (IF 3.944).
Bertini, I., Gallo, G., Korsak, M., Luchinat, C., Mao, J., and Ravera, E., Formation Kinetics and Structural Features of Beta-Amyloid Aggregates by Sedimented Solute NMR, ChemBioChem, 14, 1891-1897, 2013 (IF 3.944).
Communications at Conferences
Thomas Hosek:
- 12th Chianti-INSTRUCT Workshop on BioNMR, Electron and Nuclear Relaxation for Structural Biology, June 17-22, 2012, Montecatini Terme (Pistoia), Italy
Magdalena Korsak:
- On the last lap to Horizion 2020 - Marie Curie Actions", Florence, November 26-27, 2013
- Intensive Training Course (CS) - Marie Curie Training Network – ’’Fund acquisition and digital job hunting.’’ Castiglione dellaPescaia, Italy, May 28-31, 2014
- IDPbyNMR final meeting – “ High resolution tools to understand the functional role of protein intrinsic disorder”. Riva del Sole, Castiglione della Pescaia, Grosseto, Italy, 21-26 September 2014
- FEBS, Paris 30.08-04.09. 2014
Publications
Barbieri, L., Luchinat, E. and Banci, L., Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells, Nature Protocols 11: 1101-1111, 2016 (IF 9.67).
Mercatelli, E., Barbieri, L., Luchinat, E., and Banci, L., Direct Structural Evidence of Protein Redox Regulation Obtained by in-cell NMR, BBA - Molecular Cell Research, 1863: 198-204, 2016 (IF 5.019).
Fuccio, C., Luchinat, E., Barbieri, L., Neri, S. and Fragai, M., Algal autolysate medium to label proteins for NMR mammalian cells. J.Biomol.NMR, doi: 10.1007/s10858-016-0026-0: 2016 (IF 3.141).
Barbieri L, Luchinat E and Banci L . Protein interaction patterns in different cellular environments are revealed by in cell NMR. Scientific Reports 5:14456: DOI: 10.1038/srep14456, 2015.(IF 5.578)
Rinaldelli, M., Carlon, A., Ravera, E., Parigi, G., and Luchinat, C., FANTEN: a new web-based interface for the analysis of magnetic anisotropy-induced NMR data, J Biomol NMR, 61, 21-34, 2015 (IF 3.141).
Luchinat, E., Barbieri, L., Rubino, J. T., Kozyreva, T., Cantini, F., and Banci, L., In living cells folding and metal binding of SOD1 fALS mutants is impaired, Nat.Commun., 5, 5502-, 2014 (IF 10.742).
Rinaldelli, M., Ravera, E., Calderone, V., Parigi, G., Murshudov, G. N., and Luchinat, C., Simultaneous use of solution NMR and X-ray data REFMAC5 for joint refinement/detection of structural differences, Acta Cryst.D, D70, 958-967, 2014 (IF 7.232).
Barbieri, L., Luchinat, E., and Banci, L., Structural insight of proteins in sub-cellular compartments: in mitochondria NMR, Biochim Biophys Acta, 1843, 2492-2496, 2014 (IF 3.848).
Banci, L., Barbieri, L., Bertini, I., Luchinat, E., Secci, E., Zhao, Y., and Aricescu, A. R., Atomic-resolution monitoring of protein maturation in live human cells by NMR, Nat.Chem.Biol., 9, 297-299, 2013 (IF 14.690).
Andreini, C., Cavallaro, G., Lorenzini, S., and Rosato, A., MetalPDB: a database of metal sites in biological macromolecular structures, Nucleic Acids Res., 41, D312-D319, 2013 (IF 8.278).
Banci, L., Barbieri, L., Luchinat, E., and Secci, E., Visualization of redox-controlled protein fold in living cells, Chem.Biol., 20, 747-752, 2013 (IF 5.829).
Calcada, E. O., Felli, I. C., Hosek, T., and Pierattelli, R., The heterogeneous structural behaviour of E7 from HPV16 revealed by NMR spectroscopy, ChemBioChem, 14, 18761882, 2013 (IF 3.944).
Bhaumik, A., Luchinat, C., Parigi, G., Ravera, E., and Rinaldelli, M., NMR crystallography on paramagnetic systems: solved and open issues, Cryst.Eng.Comm., 15, 8639-8656, 2013 (IF 3.879).
Ferella, L., Luchinat, C., Ravera, E., and Rosato, A., SEDNMR: A web tool for optimizing sedimentation of macromolecular solutes for SSNMR, J.Biomol.NMR, 57, 319-326, 2013 (IF 2.845).
Luchinat, C., Parigi, G., Ravera, E., and Rinaldelli, M., Solid state NMR crystallography through paramagnetic restraints, J.Am.Chem.Soc., 134, 5006-5009, 2012 (IF 9.019).
Andreini, C., Cavallaro, G., and Lorenzini, S., FindGeo: a tool for determining metal coordination geometry, Bioinformatics, 28, 1658-1660, 2012 (IF 4.877).
Bertini, I., Ferella, L., Luchinat, C., Parigi, G., Petoukhov, M. V., Ravera, E., and Rosato, A., MaxOcc: a web portal for Maximum Occurence Analysis, J.Biomol.NMR, 53, 271-280, 2012 (IF 3.612).
Bertini, I., Case, D. A., Ferella, L., Giachetti, A., and Rosato, A., A grid-enable web portal for NMR structure refinement with AMBER, Bioinformatics, 27, 2384-2390, 2011 (IF 4.877).
Banci, L., Barbieri, L., Bertini, I., Cantini, F., and Luchinat, E., In-cell NMR in E.coli to monitor maturation steps of hSOD1, Plos ONE, 6, e23561-, 2011 (IF 4.411).