Dr. Lucia Banci
Lucia Banci is Professor of Chemistry at the University of Florence. Her research expertise is focused on structural biology,within an integrated, cellular perspective. She is working mainly in solution through high resolution NMR spectroscopy, to which she has also contributed methodological and theoretical advancements. She has been an active player in Structural Genomics projects. Her approach was driven by the "function perspective" more than by a broad coverage of genome products. As an advancement of this approach, she is now extensively contributing to the development of Integrated and Cellular Structural Biology projects, combining atomic level characterization with a cellular context. She is also extensively contributing to methodological advancements in this field.
She has recently been awarded the IUPAC Award "Distinguished Women in Chemistry" (2015) and the "Fiorino d'Oro della Città di Firenze" Gold Medal of the City of Florence.
Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R, Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nat Chem Biol, 11:772-778, 2015
Luchinat E, Gianoncelli A, Mello T, Luchinat E, Galli A, Banci L. Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1. Chem Commun, 51:584-7, 2015
Banci L, Barbieri L, Bertini I, Luchinat E, Secci E, Zhao Y and Aricescu AR. Atomic-resolution monitoring of protein maturation in live human cells by NMR. Nat Chem Biol, 9:297-299, 2013
Banci, L., Bertini, I., Calderone, V., Ciofi-Baffoni, S., Giachetti, A., Jaiswal, D., Mikolajczyk, M., Piccioli, M., and Winkelmann, J. A molecular view of an electron transfer pathway essential for iron-sulfur protein biogenesis. Proc.Natl.Acad.Sci.USA, 110:7136-7141, 2013.
Banci L, Bertini I, Cantini F, Kozyreva T, Massagni C, Palumaa P, Rubino JT and Zovo K. Human SOD1 maturation through interaction with human CCS.Proc Natl Acad Sci USA 109: 13555-13560, 2012
Banci L, Bertini I, Blazevits O, Calderone V, Cantini F, Mao J, Trapananti A, Vieru M, Amori I, Cozzolino M and Carri MT. Interaction of Cisplatin with Human Superoxide Dismutase. J Am Chem Soc 134: 7009-7014, 2012
Banci L, Barbieri L, Bertini I, Cantini F and Luchinat E. In-cell NMR in E.coli to monitor maturation steps of hSOD1. Plos ONE 6: e23561, 2011
Banci L, Bertini I, Calderone V, Cefaro C, Ciofi-Baffoni S, Gallo A, Kallergi E, Lionaki E, Pozidis C, and Tokatlidis K, Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR, Proc Natl Acad Sci USA, 108, 4811-4816, 2011
Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogoini B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R, Rational design of a meningococcal antigen inducing broad protective immunity, Sci Transl Med, 3, 97-106, 2011
Banci L, Bertini I, Cefaro C, Cenacchi L, Ciofi-Baffoni S, Felli IC, Gallo A, Gonnelli L, Luchinat E, Sideris D, Tokatlidis K., Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import., Proc Natl Acad Sci USA, 2010 Nov 23;107(47):20190-5. Epub 2010 Nov 8.
Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K and Palumaa P. Affinity gradients drive copper to cellular destinations. Nature 465: 645-648, 2010
Banci L, Bertini I, Boca M, Calderone V, Cantini F, Girotto S, and Vieru M Structural and dynamic aspects related to oligomineralization of apo SOD1 and its mutants. Proc Natl Acad Sci USA 106: 6980-6985, 2009
Banci L, Bertini I, Cefaro C, Ciofi-Baffoni S, Gallo A, Martinelli M, Sideris DP, Katrakili N and Tokatlidis K, MIA40 is and oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat Struct Mol Biol 16: 198-206, 2009
Abriata LA, Banci L, Bertini I, Ciofi-Baffoni S, Gkazonis P, Spyroulias GA, Vila AJ and Wang S, Mechanism of Cu(A) assembly. Nat Chem Biol 4: 599-601, 2008
Andreini C, Banci L, Bertini I and Rosato A. Occurence of copper through the three domains of life: a bioinformatic approach. J Proteome Res 1: 209-216, 2008.
Banci L, Bertini I, Ciofi-Baffoni S, Hadjiloi T, Martinelli M and Palumaa P. Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci USA 105: 6803-6808, 2008.
Csizmok V, Felli IC, Tompa P, Banci L and Bertini I, Structural and dynamic characterization of intrinsecally disordered human securin by NMR. J Am Chem Soc 130: 16873-16879, 2008.
Banci L, Baumeister W, Enfedaque J, Heinemann U, Schneider G, Silman I and Sussman JL. Structural proteomics: from the molecule to the system. Nat Struct Mol Biol 14: 3-4, 2007.
Banci L, Bertini I, Girotto S, Martinelli M, Vieru M, Whitelegge J, Durazo A and Valentine JS. Metal-free SOD1 forms amyloid-like oligomers: a possible general mechanism for familial ALS. Proc Natl Acad Sci USA 104: 11263-11267, 2007.
Andreini C, Banci L, Bertini I and Rosato A. Zinc through the three domains of life. J Proteome Res 5: 3173-3178, 2006.
Andreini C, Banci L, Bertini I and Rosato A. Counting the zinc proteins encoded in the human genome. J Proteome Res 5: 196-201, 2006
Arnesano F, Banci L and Piccioli M. NMR structures of paramagnetic metalloproteins. Q Rev Biophys 38: 167-219, 2006.
Banci L, Bertini I, Calderone V, Ciofi-Baffoni S, Mangani S, Martinelli M, Palumaa P and Wang S. A hint for the function of human Sco1 from different structures. Proc Natl Acad Sci USA 103: 8595-8600, 2006.
Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato Aand Voulgaris P. The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol 2: 367-368, 2006.
Banci L. MD simulations of metalloproteins. Curr Opin Chem Biol 7: 143-149, 2003.
Banci L and Rosato A. Structural genomics of proteins involved in copper homeostasis. Acc Chem Res 36: 215-221, 2003.