Dr. Lucia Banci
Lucia Banci is Professor of Chemistry at the University of Florence. Lucia Banci has a high international reputation for her original contributions and breakthroughs in Structural Biology and in biological NMR. She is recognized as a world class leader in the characterization of functional processes in a cellular context with atomic resolution. She has addressed and unraveled many aspects of the biology of metal ions in biological systems, from their homeostasis processes to the trafficking and metal incoroporation to the final receiving proteins. She developed a molecular systems biology approach which integrates structural, interaction and dynamical information with the thermodynamic properties of the processes, so to have a unified picture of the processes responsible of metal ion trafficking, with particular focus on copper and on the biogenesis of iron-sulfur cluster proteins.
Over the recent years Lucia Banci exploited the extensive knowledge of structural biology approaches through NMR expertise to develop an absolutely innovative approach to vaccine design, which she first named «Structural Vaccinology» based on the knowledge of the structure of the pathogen antigens and of the interaction pattern with antibodies, to design structure-based vaccines. With this approch she provided an essential contribution to the developement of a vaccine against meningococcus B pathogen, which is characterized by several variants, each exhibiting different epitopes on a very effective antigen. The knowledge of the structural properties allowed the design of a chimera antigen which has complete protectivity againgst all the variants.
She is one of the funders and now Director of CERM.
She is member of EMBO, of AcademiaNet and is the Italian delegate in the Council of the European Molecular Biology Laboratory (EMBL).
She has been awarded the IUPAC Award "Distinguished Women in Chemistry" (2015) and the "Fiorino d'Oro della Città di Firenze" Gold Medal of the City of Florence.
Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R, Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nat Chem Biol, 11:772-778, 2015
Luchinat E, Gianoncelli A, Mello T, Luchinat E, Galli A, Banci L. Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1. Chem Commun, 51:584-7, 2015
Banci L, Barbieri L, Bertini I, Luchinat E, Secci E, Zhao Y and Aricescu AR. Atomic-resolution monitoring of protein maturation in live human cells by NMR. Nat Chem Biol, 9:297-299, 2013
Banci, L., Bertini, I., Calderone, V., Ciofi-Baffoni, S., Giachetti, A., Jaiswal, D., Mikolajczyk, M., Piccioli, M., and Winkelmann, J. A molecular view of an electron transfer pathway essential for iron-sulfur protein biogenesis. Proc.Natl.Acad.Sci.USA, 110:7136-7141, 2013.
Banci L, Bertini I, Cantini F, Kozyreva T, Massagni C, Palumaa P, Rubino JT and Zovo K. Human SOD1 maturation through interaction with human CCS.Proc Natl Acad Sci USA 109: 13555-13560, 2012
Banci L, Bertini I, Blazevits O, Calderone V, Cantini F, Mao J, Trapananti A, Vieru M, Amori I, Cozzolino M and Carri MT. Interaction of Cisplatin with Human Superoxide Dismutase. J Am Chem Soc 134: 7009-7014, 2012
Banci L, Barbieri L, Bertini I, Cantini F and Luchinat E. In-cell NMR in E.coli to monitor maturation steps of hSOD1. Plos ONE 6: e23561, 2011
Banci L, Bertini I, Calderone V, Cefaro C, Ciofi-Baffoni S, Gallo A, Kallergi E, Lionaki E, Pozidis C, and Tokatlidis K, Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR, Proc Natl Acad Sci USA, 108, 4811-4816, 2011
Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogoini B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R, Rational design of a meningococcal antigen inducing broad protective immunity, Sci Transl Med, 3, 97-106, 2011
Banci L, Bertini I, Cefaro C, Cenacchi L, Ciofi-Baffoni S, Felli IC, Gallo A, Gonnelli L, Luchinat E, Sideris D, Tokatlidis K., Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import., Proc Natl Acad Sci USA, 2010 Nov 23;107(47):20190-5. Epub 2010 Nov 8.
Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K and Palumaa P. Affinity gradients drive copper to cellular destinations. Nature 465: 645-648, 2010
Banci L, Bertini I, Boca M, Calderone V, Cantini F, Girotto S, and Vieru M Structural and dynamic aspects related to oligomineralization of apo SOD1 and its mutants. Proc Natl Acad Sci USA 106: 6980-6985, 2009
Banci L, Bertini I, Cefaro C, Ciofi-Baffoni S, Gallo A, Martinelli M, Sideris DP, Katrakili N and Tokatlidis K, MIA40 is and oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat Struct Mol Biol 16: 198-206, 2009
Abriata LA, Banci L, Bertini I, Ciofi-Baffoni S, Gkazonis P, Spyroulias GA, Vila AJ and Wang S, Mechanism of Cu(A) assembly. Nat Chem Biol 4: 599-601, 2008
Andreini C, Banci L, Bertini I and Rosato A. Occurence of copper through the three domains of life: a bioinformatic approach. J Proteome Res 1: 209-216, 2008.
Banci L, Bertini I, Ciofi-Baffoni S, Hadjiloi T, Martinelli M and Palumaa P. Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci USA 105: 6803-6808, 2008.
Csizmok V, Felli IC, Tompa P, Banci L and Bertini I, Structural and dynamic characterization of intrinsecally disordered human securin by NMR. J Am Chem Soc 130: 16873-16879, 2008.
Banci L, Baumeister W, Enfedaque J, Heinemann U, Schneider G, Silman I and Sussman JL. Structural proteomics: from the molecule to the system. Nat Struct Mol Biol 14: 3-4, 2007.
Banci L, Bertini I, Girotto S, Martinelli M, Vieru M, Whitelegge J, Durazo A and Valentine JS. Metal-free SOD1 forms amyloid-like oligomers: a possible general mechanism for familial ALS. Proc Natl Acad Sci USA 104: 11263-11267, 2007.
Andreini C, Banci L, Bertini I and Rosato A. Zinc through the three domains of life. J Proteome Res 5: 3173-3178, 2006.
Andreini C, Banci L, Bertini I and Rosato A. Counting the zinc proteins encoded in the human genome. J Proteome Res 5: 196-201, 2006
Arnesano F, Banci L and Piccioli M. NMR structures of paramagnetic metalloproteins. Q Rev Biophys 38: 167-219, 2006.
Banci L, Bertini I, Calderone V, Ciofi-Baffoni S, Mangani S, Martinelli M, Palumaa P and Wang S. A hint for the function of human Sco1 from different structures. Proc Natl Acad Sci USA 103: 8595-8600, 2006.
Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato Aand Voulgaris P. The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol 2: 367-368, 2006.
Banci L. MD simulations of metalloproteins. Curr Opin Chem Biol 7: 143-149, 2003.
Banci L and Rosato A. Structural genomics of proteins involved in copper homeostasis. Acc Chem Res 36: 215-221, 2003.