Dr. Giacomo Parigi
Associate Professor of Chemistry
Department of Chemistry "Ugo Schiff" and Magnetic Resonance Center (CERM)
University of Florence
Via L. Sacconi 6
50019 Sesto Fiorentino (FI) - Italy

Tel: +39 055 4574240 - Fax: +39 055 4574923




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List of Publications

Giacomo Parigi was born in 1967, degree in Physics cum laude at the University of Florence (1992) and PhD in Chemistry at the University of Florence. Postdoctor, Researcher (1999-2006) and Associate Professor of Chemistry (2006-) at CERM, University of Florence. His research interests include nuclear and electron relaxation, paramagnetism-based effects in NMR, bioinformatics for protein structure calculations.

Co-author with I. Bertini and C. Luchinat of the book "Solution NMR of Paramagnetic Molecules" (Elsevier, 2001)

Co-editor with I. Bertini and K.S. McGreevy of the book "NMR of Biomolecules: Towards Mechanistic Systems Biology" (Wiley-VCH, 2012)

Co-author with I. Bertini, C. Luchinat and E. Ravera of the book "NMR of Paramagnetic Molecules" (Elsevier, 2017)

Co-editor with C. Luchinat and E. Ravera of the book "Paramagnetism in Experimental Biomolecular NMR" (RSC, 2018)

Selected recent publications

N. Rezaei-Ghaleh, G. Parigi, A. Soranno, A. Holla, S. Becker, B. Schuler, C. Luchinat, M. Zweckstetter, “Local and Global Dynamics in Intrinsically Disordered Synuclein”, Angew.Chem.Int.Ed. (2018) 57, 15262-15266.


G. Liu, M. Levien, N. Karschin, G. Parigi, C. Luchinat, M. Bennati, “One-thousand fold enhancement of high field liquid nuclear-magnetic resonance signals at room temperature”, Nat. Chem. (2017) 9, 676-680.


W. Andrałojć, Y. Hiruma, W.-M. Liu, E. Ravera, M. Nojiri, G. Parigi, C. Luchinat, M. Ubbink, “Identification of productive and futile encounters in an electron transfer protein complex”, Proc. Natl. Acad. Sci. USA (2017) 114, E1840-E1847.


N. Rammohan, K.W. MacRenaris, L.K. Moore, G. Parigi, D.J. Mastarone, L.M. Manus, L.M. Lilley, A.T. Preslar, E.A. Waters, A. Filicko, C. Luchinat, D. Ho, T.J Meade, “Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field”, Nano Letters (2016) 16, 7551–7564.


L. Benda, J. Mareš, E. Ravera, G. Parigi, C. Luchinat, M. Kaupp, J. Vaara, “Pseudo-contact NMR shifts over a paramagnetic metalloprotein (CoMMP-12) from first principles”, Angew.Chem.Int.Ed. (2016) 55, 14713-14717.


A. Carlon, E. Ravera, J. Hennig, G. Parigi, M. Sattler, C. Luchinat, “Improved accuracy from joint X-ray and NMR refinement of a protein-RNA complex structure”, J. Am. Chem. Soc. (2016) 138, 1601-1610.


M. Rotz, K. Culver, G. Parigi, K. MacRenaris, C. Luchinat, T. Odom, T.J. Meade, “High Relaxivity Gd(III)-DNA Gold Nanostars: Investigation of Shape Effects on Proton Relaxation”, ACS Nano (2015) 9, 3385-3396


J.-H. Ardenkjaer-Larsen, G.S. Boebinger, A. Comment, S. Duckett, A. Edison, F. Engelke, C. Griesinger, R.G. Griffin, C. Hilty, H. Maeda, G. Parigi, T. Prisner, E. Ravera, J. van Bentum, S. Vega, A. Webb, C. Luchinat, H. Schwalbe, L. Frydman, “Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy”, Angew.Chem.Int.Ed. (2015) 54, 9162–9185


M. Rinaldelli, E. Ravera, V. Calderone, G. Parigi, G. Murshudov, C. Luchinat, “Simultaneous Use of Solution NMR and X-ray Data in REFMAC5 for Joint Refinement/Detection of Structural Differences”, Acta Crystallographica D (2014) 70, 958–967.


A.T. Preslar, G. Parigi, M.T. McClendon, S.S. Sefick, T.J. Moyer, C. Haney, E.A. Waters, K.W. MacRenaris, C. Luchinat, S.I. Stupp, T.J. Meade, “Gd(III) Labeled Peptide Nanofibers for Reporting on Biomaterial Localization In Vivo”, ACS Nano (2014) 8, 7325-7332.


E. Ravera, L. Salmon, M. Fragai, G. Parigi, H. Al-Hashimi, C. Luchinat, “Insights into Domain-Domain Motions in Proteins and RNA from Solution NMR”, Acc. Chem. Res. (2014) 47, 3118–3126.


G. Parigi, N. Rezaei-Ghaleh, A. Giachetti, S. Becker, C. Fernandez, M. Blackledge, C. Griesinger, M. Zweckstetter, C. Luchinat, “Long-Range Correlated Dynamics in Intrinsically Disordered Proteins”, J. Am. Chem. Soc. (2014) 136, 16201–16209.


I. Bertini, C. Luchinat, G. Parigi, E. Ravera, “SedNMR: on the edge between solution and solid state NMR”, Acc. Chem. Res. (2013) 46, 2059-2069.


C. Luchinat, G. Parigi, E. Ravera, M. Rinaldelli, “Solid state NMR crystallography through paramagnetic restraints”, J. Am. Chem. Soc. (2012) 134, 5006-5009.


I. Bertini, C. Luchinat, G. Parigi, E. Ravera, B. Reif, P. Turano, “Solid State NMR of proteins sedimented by ultracentrifugation”, Proc. Natl. Acad. Sci. USA (2011) 108, 10396-10399.


D.J. Mastarone, V.S.R. Harrison, A.L. Eckermann, G. Parigi, C. Luchinat, T.J. Meade, “A Modular System for the Synthesis of Multiplexed Magnetic Resonance Probes”, J. Am. Chem. Soc. (2011) 133, 5329-5337.


I. Bertini, A. Giachetti, C. Luchinat, G. Parigi, R. Pierattelli, E. Ravera, M.V. Petoukhov, D.I. Svergun, “Conformational space of flexible biological macromolecules from average data”, J. Am. Chem. Soc. (2010) 132, 13553–13558.


I. Bertini, P. Kursula, C. Luchinat, G. Parigi, J. Vahokoski, M. Wilmanns, J. Yuan, “Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples”, J. Am. Chem. Soc. (2009) 131, 5134–5144.