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Dr. Claudio Luchinat
Professor of Chemistry
Magnetic Resonance Center
and Department of Chemistry
University of Florence
Via L. Sacconi 6
50019 Sesto Fiorentino, (FI) - Italy

Tel: +39 055 4574296 - Fax: +39 055 4574923

E-mail: luchinattomtecerm.unifi.it

 

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Curriculum Vitae (English)

List of Publications

Educational

Claudio Luchinat, born in 1952, Doctor in Chemistry cum laude at the University of Florence, Researcher at the University of Florence, full professor of Chemistry at the University of Bologna (1986-96) and Florence (1996-, CERM and Department of Chemistry). Raffaello Nasini gold medal of the Italian Chemical Society, 1989; Federchimica award, 1994; European Medal for Biological Inorganic Chemistry, 1996; "GDRM gold medal for magnetic resonance", 2001. Author of about 550 publications in Bioinorganic Chemistry, NMR and Structural Biology, and of four books.

Selected recent publications

Ravera, E., Salmon, L., Fragai, M., Parigi, G., Al-Hashimi, H. M., and Luchinat, C., Insights into domain-domain motions in proteins and RNA from solution NMR, Acc.Chem.Res., 47, 3118-3126, 2014.

 

Rinaldelli, M., Ravera, E., Calderone, V., Parigi, G., Murshudov, G. N., and Luchinat, C., Simultaneous use of solution NMR and X-ray data REFMAC5 for joint refinement/detection of structural differences, Acta Cryst.D, D70, 958-967, 2014.

 

Luchinat, C., Parigi, G., and Ravera, E., NMR technology: the competitive world of RAS biology, Nature Chem.Biol., 10, 173-174, 2014.

 

Preslar, A t., Parigi, G., McClendon, M. T., Sefick, S. S., Moyer, T. J., Haney, C. R., Waters, E. A., MacRenaris, K. W., Luchinat, C., Stupp, S. I., and Meade, T. J., Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo, ACS nano, 8, 7325-7332, 2014.

 

Corzilius, B., Michaelis, V. K., Penzel, S., Ravera, E., Smith, A., Luchinat, C., and Griffin, R. G., Dynamic nuclear polarization of 1H, 13C and 59Co in a Co(III) tris-ethylenediamine crystalline lattice doped with Cr(III), J.Am.Chem.Soc., 136, 11716-11727, 2014.

 

Parigi, G., Rezaei-Ghaleh, N., Giachetti, A., Becker, S., Fernandez, C., Blackledge, M., Griesinger, C., Zweckstetter, M., and Luchinat, C., Long-Range Correlated Dynamics in Intrinsically Disordered Proteins, J.Am.Chem.Soc., 136, 16201-16209, 4-11-2014.

 

Tarocchi, M., Polvani, S., Peired, AJ, Marroncini, G., Calamante, M., Ceni, E., Rhodes, D., Mello, G., Pieraccini, G., Quattrone, A., Luchinat, C., and Galli, A., Telomerase activated thymidine analogue pro-drug is a new molecule targeting hepatocellular carcinoma, J.Hepatol., 14, 1064-1072, 2014.

 

Cacciatore, S., Luchinat, C., and Tenori, L., Knowledge discovery by accuracy maximization, Proc.Natl.Acad.Sci.USA, 111, 5117-5122, 2014.

 

Cerofolini, L., Amato, J., Fragai, M., Giachetti, A., Limongelli, V., Luchinat, C., Novellino, E., Parrinello, M., and Randazzo, A., G-triplex structure and formation propensity, Nucleic Acids Res., 42, 13393-13404, 2014.

 

Bertini, I., Luchinat, C., Parigi, G., and Ravera, E., SedNMR: on the edge between solution and solid state NMR, Acc.Chem.Res., 46, 2059-2069, 2013.

 

Limongelli, V., De Tito, S., Cerofolini, L., Fragai, M., Pagano, B., Trotta, R., Cosconati, S., Marinelli, L., Novellino, E., Bertini, I., Randazzo, A., Luchinat, C., and Parrinello, M., The G-triplex DNA, Angew.Chem.Int.Ed., 52, 2269-2273, 2013.

 

Fragai, M., Luchinat, C., Parigi, G., and Ravera, E., Conformational freedom of metalloproteins revealed by paramagnetism-assisted NMR, Coord.Chem.Rev., 257, 2652-2667, 2013.

 

Ravera, E., Corzilius, B., Michaelis, V. K., Rosa, C., Griffin, R. G., Luchinat, C., and Bertini, I., Dynamic nuclear polarization of sedimented solutes, J.Am.Chem.Soc., 135, 1641-1644, 2013.

 

Luchinat, C., Parigi, G., Ravera, E., Rinaldelli, M., Solid state NMR cristallography through paramagnetic restraints,  J.Am.Chem.Soc., 134, 5006-5009, 2012.

 

Bertini, I., Fragai, M., Luchinat, C., Melikian, M., Toccafondi, M., Lauer, J.L., Fields, G.B., Structural basis for metalloproteinase 1-catalyzed collagenolysis, J.Am.Chem.Soc., 134, 2100-2112, 2012.

 

Bertini, I., Luchinat, C., and Parigi, G., Ravera, E., Reif, B., Turano, P., Solid-state NMR of proteins sedimented by ultracentrifufation ,  Proc.Natl.Acad.Sci.USA, 108, 10396-10399, 2011.

 

Bertini, I., Gonnelli, L., Luchinat, C., Mao, J., Nesi, A., A new structural model Aß40 fibrils, J.Am.Chem.Soc., 133, 16013-16022, 2011.

 

Bertini, I., Cacciatore, S., Jensen, B.V., Schou, J.V., Johansen J.S., Kruhøffer, M., Luchinat, C., Nielsen, D. L., and Turano, P., Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer,  Cancer Res., 356-364, 2012.

 

Bertini, I., Luchinat, C., and Parigi, G., Moving the frontiers in solution solid state bioNMR. A celebration of Harry Gray's 75th birthday,  Coord.Chem.Rev., 255, 649-663, 2011.


Banci, L., Bertini, I., Blazevits, O., Cantini, F., Lelli, M., Luchinat, C., Mao, J., and Vieru, M., NMR characterization of a "fibril-ready" state of demetallated wild-type superoxide dismutase,  J.Am.Chem.Soc., 133, 345-349, 2011.


Mastarone, D. J., Harrison, V. S. R., Eckermann, A. L., Parigi, G., Luchinat, C., and Meade, T. J., A modular system for the synthesis of multiplexed MR probes,  J.Am.Chem.Soc., 133,5329-5337, 2011.

Corzilius, B., Smith, A.A., Barnes, A.B., Luchinat, C., Bertini, I., Griffin, R.G., High-Field Dynamic Nuclear Polarization with High-Spin Transition Metal Ions, J. Am. Chem. Soc., 133, 5648-5651, 2011.

Bertini, I., Luchinat, C., Spectroscopy: Unexpected interactions, Nature, 470:469-470, 2011.

 

Polvani, S., Calamante, M., Foresta, V., Ceni, E., Mordini, A., Quattrone, A., D'Amico, M., Luchinat, C., Bertini, I., and Galli, A., Acycloguanosyl 5'-thymidyltriphosphate, a new thymidine analogue pro-drug for pancreatic cancer therapy, Gastroenterology140, 709-720, 2011.

 

Bertini, I., Giachetti, A., Luchinat, C., Parigi, G., Petoukhov, M. V., Pierattelli, R., Ravera, E., and Svergun, D. I., Conformational space of flexible biological macromolecules from average data, J.Am.Chem.Soc., 132, 13553-13558, 2010.

 

Bertini, I., Emsley, L., Lelli, M., Luchinat, C., Mao, J., and Pintacuda, G., Ultra-Fast MAS solid-state NMR permits extensive 13C and 1H detection in paramagnetic metalloproteins, J.Am.Chem.Soc., 132, 5558-5559, 2010.

 

Bertini, I., Bhaumik, A., De Paepe,G., Griffin, R. G., Lelli, M., Lewandowski, J., and Luchinat, C., High-resolution solid state NMR structure of a 17.6 kDa protein, J. Am. Chem. Soc., 132: 1032-1040, 2010.

 

Bertini, I., Kursula, P., Luchinat, C., Parigi, G., Vahokoski, J., Willmans, M., and Yuan, J., Accurate solution structures of proteins from X-ray data and minimal set of NMR data: calmodulin peptide complexes as examples, J.Am.ChemSoc., 131: 5134-5144, 2009

 

Reese, M., Tuerke, M.-T, Tkach, I., Parigi, G., Luchinat, C., Marquardsen, T., Tavernier,A., Hofer, P., Engelke, F., Griesinger, C., and Bennati, M., 1H and
13C dynamic nuclear polarization in aqueous solution with a two-field (0.35T/14T) shuttle DNP spectometer, J.Am.Chem.Soc., 131: 15086-15087, 2009.

 

Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T. L.,Homans, S. W., Kessler, H., Luchinat, C., Meyer, B., Oschkinat, H., Peng, J., Schwalbe, H.,and Siegal, G., Perspectives on NMR in drug discovery: a technique comes of age, Nature Rev.Drug Discov., 7: 738-745, 2008.

 

Bertini, I., Fragai, M., Luchinat, C., and Talluri, E., Water-based ligand screening for paramagnetic metalloproteins, Angew.Chem.Int.Ed., 47: 4533-4537, 2008

 

Balayssac, S., Bertini, I., Bhaumik, A., Lelli, M., and Luchinat, C., Paramagnetic shifts in solid-state NMR of proteins to elicit structural information., Proc.Natl.Acad.Sci.USA, 105: 17284-17289, 2008.

 

Bertini, I., Calderone, V., Fragai, M., Jaiswal, R., Luchinat, C., Melikian, M., Mylonas, E., and Svergun, D., Evidence of reciprocal reorientaion of the catalytic and hemopexin-like domains of full-length MMP-12, J.Am.Chem.Soc.: 130, 7011-7021, 2008

 

Assfalg, M., Bertini, I., Colangiuli, D., Luchinat, C., Schaefer, H., Schuetz, B., and Spraul, M., Evidence of different metabolic phenotypes in humans, Proc. Natl. Acad. Sci. USA. 105:1420-1424, 2008.

 

Luchinat, C. and Parigi, G., Collective relaxation of protein protons at very low magnetic field: a new window on protein dynamics and aggregation., J.Am.Chem.Soc., 129, 1055-1064, 2007.

 

Bertini, I., Gupta, Y. K., Luchinat, C., Parigi, G., Peana, M., Sgheri, L., and Yuan, J, Paramagnetism-Based NMR Restraints Provide Maximum Allowed Probabilities for the Different Conformations of Partially Independent Protein Domains, J.Am.Chem.Soc., 129, 12786-12794, 2007.

 

Bertini, I., Calderone, V., Fragai, M., Giachetti, A., Loconte, M., Luchinat, C., Maletta, M., Nativi, C., and Yeo, K. J., Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases, J.Am.Chem.Soc., 129, 2466-2475, 2007.

 

Balayssac, S., Bertini, I., Lelli, M., Luchinat, C., and Maletta, M., Paramagnetic ions provide precious structural restraints in solid-state NMR ofproteins, J.Am.Chem.Soc., 129, 2218-2219, 2007.

 

Major, J. L., Meade, T. J., Parigi, G., and Luchinat, C., The Synthesis and In-Vitro testing of a Zn(II)-Activated MR contrast agent, Proc.Natl.Acad.Sci.USA, 104, 13881-13886, 2007.

 

Bermel, W., Bertini, I., Felli, I. C., Lee, Y.-M., Luchinat, C., and Pierattelli, R., Protonless NMR experiments for sequence-specific assignment of backbone nuclei in unfolded proteins, J.Am.Chem.Soc. , 128: 3918-3919, 2006.

 

Balayssac, S., Bertini, I., Luchinat, C., Parigi, G., and Piccioli, M., 13C direct detected NMR increases the detectability of residual dipolar couplings, J.Am.Chem.Soc. , 128: 15042-15043, 2006.

 

Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Maletta, M., and Yeo, K. J., Snapshots of the Reaction Mechanism of Matrix Metalloproteinases, Angew.Chem.Int.Ed , 45, 7952-7955, 2006.

 

Fragai, M., Luchinat, C., and Parigi, G., "Four-dimensional" protein structures: examples from metalloproteins, Acc.Chem.Res. , 39: 909-917, 2006.

 

Bertini, I., Calderone, V., Cosenza, M, Fragai, M., Lee, Y.-M., Luchinat, C., Mangani, S., Terni, B., and Turano, P., Conformational variability of MMPs: beyond a single 3D structure, Proc.Natl.Acad.Sci.USA, 102: 5334-5339, 2005.

 

Calderone, V., Del Bianco, C., Dolderer, B, Echner, H., Hartmann, H. J., Luchinat, C., Mangani, S., and Weser, U., The crystal structure of yeast copper thionein: The solution of a long-lasting enigma, Proc.Natl.Acad.Sci.USA, 102: 51-56, 2005.

 

Bertini, I., Gupta, Y. K., Luchinat, C., Parigi, G., Schlörb, C., and Schwalbe, H., NMR spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz, Angew.Chem.Int.Ed., 44: 2-4, 2005.