CERM
 | | Welcome to the
Magnetic Resonance Center (CERM) CERM is a center for research, knowledge transfer, and higher education of the University of Florence, located at the Polo Scientifico (Scientific Campus) in Sesto Fiorentino. The Center is a research infrastructure for NMR in the Life Sciences supported by the European Community. |
Research Activity
 | | Goals of our Research in Structural Biology 1) Encourage activities and competencies as a world-class infrastructure in NMR that are second to none
2) Use of a bioinformatics approach that allows for the prioritization of proteins of interest
3) Production of proteins using approaches that lend themselves to high-throughput research
4) Structural determination and study of protein-protein/protein-ligand interactions using NMR, and when appropriate, X-ray technologies
5) Drug design and development at all stages, from planning to chemical synthesis to control of target interaction To learn more about the research activities of CERM, please go here or follow the links above. |
Access to Unique Instrumentation
 | | Access to Instrumentation Provided by CIRMMP The collection of instrumentation at CERM is among the most advanced in the world. The Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine Paramagnetiche (CIRMMP) provides access to equipment at a national and European level. Instruments include magnets from 400 MHz to 900 MHz, many equipped with unique probes for disparate experimental needs. Also present are relaxometers and an array of tools for research in structural biology. To learn more about our instrumentation and access, please click here. |
Academic Opportunities
 | | International Doctorate in Structural Biology and Marie Curie Fellowships CERM is the reference institution for the International Doctorate in Structural Biology, organized in collaboration with the Universities of Frankfurt and Utrecht. CERM is active as a Marie Curie training site to host European Ph.D. students, and has organized many international conferences. The CERM staff is also involved with students during their undergraduate years, and organizes countless seminars and courses for the training of internal personnel. |
CERM in the Headlines:
HRH the Princess of Thailand Chulabhorn Mahidol visits CERM
HRH Chulabhorn Mahidol, Princess of Thailand and President of the Chulabhorn Research Institute, visited CERM on August 24th. She is pictured here with the Director of CERM, Iv... Read More ...
Ivano Bertini featured in Nature Chemical Biology
Building on his contributions to NMR methodologies for studying metalloproteins, Bertini has been instrumental in bringing together inorganic chemists and biologists interested in metals in biology. H... Read More ...
Amyotrophic Lateral Sclerosis - Protein Cause Discovered
(September 18, 2007) The causes and the molecular mechanism of the malfunctioning of this protein have been characterized by researchers from the Florence-based company FiorGen. Supe... Read More ...
Archives
News and publicity archives dating back to 2000 ... Read More ...
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Hot off the Presses:
CASD-NMR: critical assessment of automated structure determination by NMR
NMR spectroscopy is the only technique for the determination of the solution structure of biological macromolecules. This typically requires both the assignment of resonances and a labor-intensive analysis of multidimensional NOESY spectra, where peaks are matched to assigned resonances. Software tools for the full automation of the NOESY assignment and the structure calculation steps have the potential to boost the efficiency, reproducibility and reliability of NMR structures. Within the e-NMR project (www.e-nmr.eu), which is funded by the European Commission (Project number 213010), we are developing an approach to assess whether such automated methods can indeed produce structures that closely match those manually refined using the same experimental data (the 'reference structures'). The concept closely resembles that of other community-wide experiments, such as CASP, the Critical Assessment of Techniques for Protein Structure Prediction, and CAPRI, the Critical Assessment of Prediction of Interactions. At variance with both CASP and CAPRI, CASD-NMR is entirely based on experimental data, presenting special issues in assembling, organizing, and distributing these data among participants. [...continued]
Click here for a link to the full article.
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