Articles

Ivano Bertini, Claudio Luchinat, Giacomo Parigi, Enrico Ravera

NMR of Paramagnetic Molecules

Applications to Metallobiomolecules and Models
 

Elesevier, 2016

 

The book presents the basic theory of the unpaired electron-nucleus coupling and the consequences on nuclear chemical shift and relaxation. The types of information obtained from the various metal ions containing molecules are discussed. Solution and solid state NMR experiments for paramagnetic molecules and biomolecules are presented. Readers will learn how to interpret the NMR spectra of paramagnetic molecules, improve experimental techniques, and strengthen their understanding of the underlying theory and applications.

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Download a sample chapter: Chapter 3

 Key Features:

  • Reflects all advances in the field in a completely updated new edition
  • Presents new material on self-orientation residual dipolar couplings, solid state NMR, dynamic nuclear polarization, and paramagnetic restraints for structure calculations
  • Includes information relevant to paramagnetic molecules, metallobiomolecules, paramagnetic compounds, and paramagnetic NMR spectroscopy
  • Presents specific examples of paramagnetic inorganic species and experimental techniques for structure characterization

Contents:
1. Introduction
2. The Hyperfine Shift
3. The Effect of Partial Orientation: Residual Dipolar Couplings
4. Relaxation
5. High Resolution Solid-State NMR in Paramagnetic Molecules
6. Chemical Exchange, Chemical Equilibria and Dynamics
7. Transition Metal Ions: Shift and Relaxation
8. Lanthanoids and Actinoids: Shift and Relaxation
9. Paramagnetic Restraints for Structure and Dynamics of Biomolecules
10. Relaxometry and Contrast Agents for MRI
11. Magnetic Coupled Systems
12. Hints on Experimental Techniques
Appendices

From the Preface:
"Applications of NMR to paramagnetic molecules and biomolecules, both in solution and in the solid state, keep growning both in number and sophistication. They represent a respectable share of all NMR activity. For NMR experiments on paramagnetic systems, one should understand the general theory of NMR and, on top of this, the theory of the electron-nucleus interaction and its consequences for the NMR parameters. For these reasons, the field of NMR of paramagnetic molecules has its own niche in the entire scientific panorama. Within this book, the authors aim to provide an up-to-date tool for everyone wishing to understand, predict, and exploit -or minimize- the effects of paramagnetic centers on the NMR spectra of molecules and biomolecules."

New to this edition:

  • self-orientation residual dipolar couplings
  • solid-state NMR
  • dynamic nuclear polarization
  • contrast agents for magnetic resonance imaging
  • paramagnetic restraints for structure calculations

Since the previous edition of this book was published, there have been many advancements in the field of paramagnetic NMR spectroscopy. This completely updated and expanded edition contains the latest fundamental theory and methods for mastery of this analytical technique. Users will learn how to interpret the NMR spectra of paramagnetic molecules, improve experimental techniques, and strengthen their understanding of the underlying theory and applications.

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