The Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) was founded in 1994 among the universities of Florence, Siena and Bologna to develop and coordinate resources in a scientific field of growing interest, the study of metalloproteins and metalloenzymes.
CIRMMP manages and partially owns one of the most well-equipped NMR laboratories in the world: the Centro di Risonanze Magnetiche (CERM). The center is equipped with a 950 MHz, 900 MHz, 850 MHz WB, 800 MHz, 700 MHz WB, 2 x 700 MHz, 2 x 600 MHz, a 500 MHz and a 400 MHz magnet, besides other routine instruments, as well as one relaxometer. Click here to learn more about CERM's instrumentation.
The 500, 700, 800, 900 and 950 MHz magnets are equipped with cryoprobes. Biophysical instrumentation such as absorbtion and CD spectroscopy fluorescence, microcalorimetry, and stopped flow tools are operative at CERM, whereas EPR mass spectroscopy and X-ray facilities are also available in flanking laboratories. CIRMMP also supports protein production with a well-equipped and robotized molecular biology laboratory for high throughput production.
These instruments are tools for structural biology studies in the post-genomic era. Structures of proteins are solved and the relation between their structure and activity is studied, as well as protein-protein recognition and interactions between DNA/RNA and proteins for the investigation of regulation. At CERM, dozens of protein structures in solution have been solved and new methodologies for obtaining such structures are continually being developed.
CIRMMP has provided a service for magnetic resonance at the European level since 1994, and also supports a national service for private and public research institutions through a national scientific committee.
CIRMMP is also very active in the education of graduate students and post-doctoral researchers. Click here to access the PhD program.