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Ivano Bertini Via Luigi Sacconi 6 I-50019 Sesto Fiorentino (FI) – Italy Phone: +39 055 457 4272 Fax: +39 055 457 4271 e-mail: bertini@cerm.unifi.it |
Links
Educational
Activities
Corso di
Laurea in Biotechnologie Dottorato di Ricerca in Scienze Chimiche |
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Ivano
Bertini was born on December 6, 1940 in Pisa, Italy. He obtained the Italian degree of Doctor
of Chemistry at the University of Florence in 1964 and the Libera Docenza in
1969. He became Full Professor of General
and Inorganic Chemistry in 1975 at the University of Florence, where he is to
this day. He received the Laurea
Honoris Causa from the University of Stockholm in 1998, Ioannina in 2002 and
Siena in 2003. He is a member of the
Academia Europaea and the Italian Accademia dei Lincei, and is or has been on
the editorial staff or advisory board of over 20 of the most authoritative
journals in chemistry, biochemistry and inorganic chemistry. After beginning his research in theoretical/physical
inorganic chemistry, since 1975 he has studied the structure-function
relationship of metalloproteins through biophysical methods. In 1990, he
transformed his lab into an NMR lab for structural biology of
metalloproteins, and eventually pioneered the exploitation of genome data
banks. He has pursued advancements in technology for solution structure
determination, particularly for paramagnetic metalloproteins, and developed
specific software applications. He
has studied electron and nuclear relaxation from both experimental and
theoretical points of view. He has
also established a molecular biology department for high-throughput protein
expression in structural genomics projects on metalloproteins. Recently he
has begun browsing genomes for pharmaceutical targets. He has published over
600 research articles and has solved more than 100 protein structures. In 1999
he founded the present Center of Magnetic Resonance (CERM) at the University
of Florence in an independent and prestigious building hosting an impressive
battery of NMR spectrometers. The Center constitutes a major NMR
infrastructure in the Life Sciences. Flanking
laboratories and spin-off institutions have flourished around CERM in the
fields of biotechnology and drug discovery thanks to his leadership. |
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Selected Publications: |
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Andreini C, Banci L, Bertini I, et al, 2006,
Counting the zin-proteins encoded in the human genome, J Prot Res
5(1)196-201. Banci L, Bertini I, Cantini F, et al, 2006, The
Atx1-Ccc2 complex is a metal-mediated protein-protein interaction, Nat Chem
Bio 2(7)367-8. Bertini I, Calderone V, Cosenza M, et al,
2005, Conformational variability of matrix metalloproteinases: beyond a
single 3D structure, Proc Natl Acad Sci USA 102(15)5334-9. Bertini I, Luchinat C, Parigi G, et al, 2005,
NMR spectroscopy of paramagnetic metalloproteins, Chem Bio Chem 6(9)1536-49. Arnesano F, Banci L, Bertini I, et al, 2004,
The unusually stable quaternary structure of human Cu, Zn-superoxide
dismutase 1 is controlled by both metal occupancy and disulfide status, J Bio
Chem 279(46)47998-8003. Arnesano F, Banci L, Bertini I, et al, 2003, A
redox switch in CopC: An intriguing copper trafficking protein that binds
copper(I) and copper(II) at different sites, Proc Natl Acad Sci USA
100(7)3814-9. Assfalg M, Bertini I, Dolfi A, et al, 2003,
Structural model for an alkaline form of ferricytochrome c, J Am Chem Soc
125(10)2913-22. Balatri E, Banci L, Bertini I, et al, 2003,
Solution structure of Sco1: A thioredoxin-like protein involved in cytochrome
c oxidase assembly, Structure 11(11)1431-43. Arnesano F, Banci L, Bertini I, et al, 2002, Metallochaperones
and metal-transporting ATPases: A comparative analysis of sequences and
structures, Gen Res 12(2) 255-71. Barbieri R, Bertini I, Cavallaro G, et al,
2002, Paramagnetically induced residual dipolar couplings for solution
structure determination of lanthanide binding proteins, J Am Chem Soc
124(19)5581-7. Arnesano F, Banci L, Bertini I, et al, 2001, Solution
structure of the Cu(I) and Apo forms of the yeast metallochaperone, Atx1,
Biochem 40(6)1528-39. Arnesano F, Banci L, Bertini I, et al, 2001, Characterization
of the binding interface between the copper chaperone Atx1 and the first
cytosolic domain of Ccc2 ATPase, J Bio Chem 276(44)41365-76. Bertini I, Janik MBL, Lee YM, et al, 2001, Magnetic
susceptibility tenser anisotropies for a lanthanide ion series in a fixed
protein matrix, J Am Chem Soc 123(18)4181-8. Bertini I, Lee YM, Luchinat C, et al, 2001, Locating
the metal ion in calcium-binding proteins by using cerium(III) as a probe,
Chem Bio Chem 2(8)550-8. Allegrozzi M, Bertini I, Janik MBL, et al,
2000, Lanthanide-induced pseudocontact shifts for solution structure
refinements of macromolecules in shells up to 40 angstrom from the metal ion,
J Am Chem Soc 122(17)4154-61. Banci L, Bertini I, Gray HB, et al, 1997, Solution
structure of oxidized horse heart cytochrome c, Biochem 36(32)9867-77. Banci L, Bertini I, Bren KL, et al, 1997, Solution
structure of oxidized Saccharomyces cerevisiae iso-1-cytochrome c, Biochem
36(29)8992-9001. Banci L, Bertini I, Bren KL, et al, 1996, The
use of pseudocontact shifts to refine solution of paramagnetic
metalloproteins: Met80Ala cyano-cytochrome c as an example, J Bio Inorg Chem
1(2)117-26. Bertini I, Capozzi F, Luchinat C, et al, 1994,
The FE4S4 centers in ferredoxins studied through proton and carbon hyperfine
coupling – sequence-specific assignment of cysteines in ferredoxins from
clostridium-acidi-urici and clostridium-pasteurianum, J Am Chem Soc 116(2)651-60. Bertini I,Turano P, Vila AJ, 1993, Nuclear
magnetic resonance of paramagnetic metalloproteins, Chem Rev 93(8)2833-932. |
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