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CERM: a Center for Research, Transfer and Higher Education of the University of Florence
CERM and CIRMMP jointly run an NMR Infrastructure which is one of the most well-equipped NMR laboratories in the world
Instruct is a pan-European Research Infrastructure providing expertise and access to high quality instruments for structural cell biology researchers
Main and satellite activities of CERM/CIRMMP
Research Areas at CERM: 70 researchers engaged in a variety of fields are working at CERM
CERM offers an International Doctorate Structural Biology and typically hosts approximately 40 PhD students and post-docs
CERM has active collaborations with a number of industrial partners
CERM applies Nuclear Magnetic Resonance (NMR) to fundamental questions in the Life Sciences.
A wide range of high-field NMR instruments that allow users to study the structure and dynamics of large molecules both in solution- and solid-state are available.

Prof_Bertini 

Dr. Ivano Bertini
Professor of Chemistry
Magnetic Resonance Center
and Department of Chemistry
University of Florence
Via L. Sacconi 6
50019 Sesto Fiorentino, (FI) - Italy

Tel: +39 055 4574272 - Fax: +39 055 4574271

E-mail: bertinitomtecerm.unifi.it

 

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Curriculum Vitae (Complete)

 

Curriculum Vitae (Concise)

 

List of Publications


Educational:

Corso di Laurea in Chimica

 

Ivano Bertini was born on December 6, 1940 in Pisa, Italy. He obtained the Italian degree of Doctor of Chemistry at the University of Florence in 1964 and the Libera Docenza in 1969. He became Full Professor of General and Inorganic Chemistry in 1975 at the University of Florence, where he is to this day. He received the Laurea Honoris Causa from the University of Stockholm in 1998, Ioannina in 2002 and Siena in 2003. He is a member of the Academia Europaea and the Italian Accademia dei Lincei, and is or has been on the editorial staff or advisory board of over 20 of the most authoritative journals in chemistry, biochemistry and inorganic chemistry.

After beginning his research in theoretical/physical inorganic chemistry, since 1975 he has studied the structure-function relationship of metalloproteins through biophysical methods. In 1990, he transformed his lab into an NMR lab for structural biology of metalloproteins, and eventually pioneered the exploitation of genome data banks. He has pursued advancements in technology for solution structure determination, particularly for paramagnetic metalloproteins, and developed specific software applications. He has studied electron and nuclear relaxation from both experimental and theoretical points of view. He has also established a molecular biology department for protein expression in structural genomics projects on metalloproteins. Recently he has begun browsing genomes for pharmaceutical targets. He has published over 650 research articles and has solved more than 150 protein structures.

In 1999 he founded the present Magnetic Resonance Center (CERM) at the University of Florence in an independent and prestigious building hosting an impressive battery of NMR spectrometers. The Center constitutes a major NMR infrastructure in the Life Sciences. Flanking laboratories and spin-off institutions have flourished around CERM in the fields of biotechnology and drug discovery thanks to his leadership.

Selected recent publications

Polvani, S., Calamante, M., Foresta, V., Ceni, E., Mordini, A., Quattrone, A., D'Amico, M., Luchinat, C., Bertini, I., and Galli, A., Acycloguanosyl 5 -thymidyltriphosphate, a Thymidine Analogue Prodrug Activated by Telomerase, Reduces Pancreatic Tumor Growth in Mice. Gastroenterology, 140, 709-720, 2011.

Bertini, I., Felli, I. C., Gonnelli, L., Vasantha Kumar, M. V., and Pierattelli, R., 13C direct-detection biomolecular NMR spectroscopy in living cells. Angew.Chem.Int.Ed., 50, 1-4, 2011.

Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K and Palumaa P. Affinity gradients drive copper to cellular destinations. Nature 465: 645-648, 2010.

Bertini I, Cavallaro G and McGreevy KS. Cellular copper management - a user's guide.  Coord Chem Rev 254: 506-524, 2010.

Turano P, Lalli D, Felli IC, Theil EC and Bertini I. NMR reveals a pathway for iron mineral precursors to the central cavity of ferritin. Proc Natl Acad Sci USA 107: 545-550, 2010.

Madl T, Felli IC, Bertini I and Sattler M. Structural analysis of protein interfaces from 13C direct-detect paramagnetic relaxation enhancements. J Am Chem Soc 132: 7285-7287, 2010.

 

Mori M, Kateb F, Bodenhausen G, Piccioli M and Abergel D. Towards structural dynamics: protein motions viewed by chemical shift modulations and direct detection of C'N multiple-quantum relaxation. J Am Chem Soc 132: 3594-3600, 2010.

 

Rosato, A., Bagaria, A., Baker, D., Bardiaux, B., Cavalli, A., Doreleijers, J. F., Giachetti, A., Guerry, P., Guntert, P., Herrmann, T., Huang, Y. J., Jonker, H. R., Mao, B., Malliavin, T. E., Montelione, G. T., Nilges, M., Raman, S., van der, Schot G., Vranken, W. F., Vuister, G. W., and Bonvin, A. M., CASD-NMR: critical assessment of automated structure determination by NMR. Nat.Methods, 6, 625-626, 2009.

Andreini, C., Bertini, I., and Rosato, A., Metalloproteomes: a bioinformatic approach.  Acc.Chem.Res.,  2009.

Banci, L., Bertini, I., Cefaro, C., Ciofi-Baffoni, S., Gallo, A., Martinelli, M., Sideris, D. P., Katrakili, N., and Tokatlidis, K., MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat.Struct.Mol.Biol., 16, 198-206, 2009.

Banci, L., Bertini, I., Boca, M., Calderone, V., Cantini, F., Girotto, S., and Vieru, M., Structural and dynamic aspects related to oligomineralization of apo SOD1 and its mutants. Proc Natl Acad Sci USA, 106, 6980-6985, 2009.

Sideris, D. P., Petrakis, N., Katrakili, N., Mikropoulou, D., Gallo, A., Ciofi-Baffoni, S., Banci, L., and Bertini, I., A novel targeting signal primes precursors for cysteine docking onto Mia40 in mitochondrial oxidative folding. J.Cell Biol., 187, 1007-1022, 2009.

Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T. L., Homans, S. W., Kessler, H., Luchinat, C., Meyer, B., Oschkinat, H., Peng, J., Schwalbe, H., and Siegal, G., Perspectives on NMR in drug discovery: a technique comes of age.  Nature Rev.Drug Discov.,  7, 738-745, 2008.

Abriata, L. A., Banci, L., Bertini, I., Ciofi-Baffoni, S., Gkazonis, P., Spyroulias, G. A., Vila, A. J., and Wang, S., Mechanism of Cu(A) assembly.  Nat.Chem.Biol., 4, 599-601, 2008.

Bertini, I., Fragai, M., Luchinat, C., and Talluri, E., Water-based ligand screening for paramagnetic metalloproteins.  Angew.Chem.Int.Ed., 47, 4533-4537, 2008.

Assfalg, M., Bertini, I., Colangiuli, D., Luchinat, C., Schaefer, H., Schuetz, B., and Spraul, M., Evidence of different metabolic phenotypes in humans. Proc Natl Acad Sci USA, 105, 1420-1424, 2008.

Balayssac, S., Bertini, I., Bhaumik, A., Lelli, M., and Luchinat, C., Paramagnetic shifts in solid-state NMR of proteins to elicit strucutral information.  Proc Natl Acad Sci USA, 105, 17284-17289, 2008.